Founder of Health Rising and Phoenix Rising
"We see an unexpected link between cellular energetics and major depression, which has always been seen as a mood disorder. We were surprised at the observation that there was a difference in mitochondrial DNA--so surprised it took us a long time to convince ourselves it was real, and not an artifact."
While searching through genes in a large study....
The researchers noticed something rather unusual in the DNA. The samples taken from women with a history of stress-related depression contained more mitochondrial DNA than other samples."Our most notable finding is that the amount of mitochondrial DNA changes in response to stress," says Professor Jonathan Flint of the University of Oxford.Mitochondria are compartments in cells responsible for generating energy. An increase in mitochondrial DNA suggests a change in mitochondria and cellular energetics, Flint explains.They proposed that the molecular changes they observed might reflect the body's way of coping with major environmental stressors. As our brains perceive a threat--lack of food or a history of abuse, for example--it may initiate a series of protective metabolic changes.
Does that suggest you could reduce depression by boosting the mitochrondria?"Depression might in some sense be considered a metabolic reaction to perceived stress," Flint says.
Read more: http://www.science20.com/news_articles/depression_leaves_a_metabolic_signature_on_mitochondria-155061#ixzz3YK3gnfMU