Naproxen for inflammation which might be at root of CFS

[eveloftus]

Today I started 5 days of Naproxen, because inflammation is strongly suspected to be at the root of CFS. If it helps I will then take low dose aspirin daily.
Has anyone tried it?

 

[Creekside]

I get the impression that actual inflammation is looking less likely for ME, but some other non-inflammatory immune activity is going on. An anti-inflammatory drug might help if it works by reducing that unknown immune activity, but since we don't know precisely what that activity is, it's a random gamble.

Also, given how ME works, it makes no difference whether the drug does or doesn't work for someone else; the only way to know whether it works for you is to try it yourself.

I tried cyclosporin, which is a potent immunosuppressant. No effect on my ME.

 

[pamojja]

Today I started 5 days of Naproxen, because inflammation is strongly suspected to be at the root of CFS.

Last October, I was prescribed Naproxen against new-onset joint pain. I suspect rheumatoid arthritis. To find out definitely, it will take this November this year, the first possible appointment with a specialist.

I had already kidney damage from anti-inflammation painkillers in the past. So I wouldn't want to take such painkillers long-term, regularly. Therefore, as an alternative, I remembered Giuliano's 4-herb synergy.

Actually all 4 herbs already in use in my comprehensive supplementation, but reduced the last couple of years due to experience cessation of real PEMs 7 years ago. Increased all, including GLA, again, and there is rarely the need for an infrequent low-dose naproxen against joint-pain already.

I fear to my appointment in November, there will be no reason for the long awaited consultation anymore.

 

[Ramona Fernandez]

It is pretty clear that inflammation plays a huge roll in most illness, never mind ME/CFS which is unusually affected by inflammation.

I have a ton of inflammation after 54 years of this illness.

My doctor is willing to start me on a trial of LDN which, if successful, would be something I take long term. I wouldn't expect it to work in only five days.

I cannot report on it yet because major and minor surgeries mean I have not been able to start it. I have another surgery in three weeks, so I won't be really testing it out for at least another month.

I do not understand why you would switch to aspirin from Naproxen. Please explain.

A regular dose of Naproxen would have quite a different effect than LDN.

 

[TVB]

Today I started 5 days of Naproxen, because inflammation is strongly suspected to be at the root of CFS. If it helps I will then take low dose aspirin daily.
Has anyone tried it?

The inflammation is caused by something in your system. It will offer relief, but undoubtedly not correct the cause. Wish you luck.

 

[Ramona Fernandez]

The inflammation is caused by something in your system. It will offer relief, but undoubtedly not correct the cause. Wish you luck.

Well, there is no actual treatment for ME as we all know. I think it is correct to state that inflammation is at the root of the disease though. By that I mean that inflammation causes many if not most of the symptoms. We also now know that inflammation causes all sorts of disease processes.

I would be gratified to know the cause of ME before I die after 55 years of suffering. We won't get a cure until we know what the disease actually is.

 

[Creekside]

I think it is correct to state that inflammation is at the root of the disease though.

No, I'm pretty sure that the studies on inflammatory markers generally do not show general inflammation in ME. I'm also pretty sure that elevated markers are not found in all PWME. Some PWME have inflammation due to other causes, which may make ME symptoms worse, and treating that inflammation may reduce but not eliminate ME symptoms.

Also, you might want to check the actual definition of "inflammation", since it's quite specific, and frequently misused. There are other ways for the immune system(s, since we have several separate ones) to be active without qualifying as inflammation.