Wonder if killing the microglial cells entirely is as good as calming them?
Full text here: https://www.medicalnewsbulletin.com/potential-new-treatment-ms-fostering-remyelination-nimodipine/Using this mouse model, they found that treatment with nimodipine had multiple benefits: It decreased the rate of demyelination, increased oligodendrocyte survival, and, as a result, also fostered remyelination of the nerve cells.
Researchers attributed these results to a combination of factors. It is believed that some of the beneficial effects of nimodipine were due to the decreased amount of calcium coming into the cells that can cause damage to the cellular structures and the surrounding cell environment.
In addition, it was found that treatment with nimodipine caused microglia cell death. Microglia are cells in the brain that are involved in the body’s immune response. These cells release molecules such as nitric oxide and reactive oxygen species, which are toxic to oligodendrocytes. Thus, their death is thought to have further improved the cell environment to enable the oligodendrocytes to survive and continue producing myelin. This result was neither expected nor found to be mediated via mechanisms linked to the blockade of calcium.