Clonidine Is…. A ‘sympatholytic’ (sympathetic nervous system suppressing) drug, Clonidine works by activating alpha 2 adrenergic receptors in the brain and inhibiting norepinephrine release.  Clonidine also reduces blood pressure and heart rate. Clonidine is used to treat a wide variety of disorders and conditions including high blood pressure, neuropathic pain, … Continue reading Clonidine (Kataprex, Nexiclone, Duriclone) in Chronic Fatigue Syndrome, POTS and Fibromyalgia