My ME/CFS is probably caused by chronic exposure to water-damaged buildings. I am living in a relatively clean home now, but I still find myself flaring up if I enter a place that is toxic from water damage. I can suffer an acute reaction that doesn't fully resolve for 1-2 days after spending 10 minutes or less in some places that don't even smell moldy, and I've been trying to understand why I'm still primed to be so reactive. I recently found this article, and I think it suggests the answer: the nose is super sensitive to pathogens and their antigens, and is responsible for the "call to arms" for the immune system. When you add the pre-existing burden of chronic sinusitis/sinus infection and years of living and working in water-damaged building to sensitize you, it just pushes your body over the edge when you breathe in that stuff. Any thoughts?
Immune System Kick-Started in Moist Nasal Lining in Sinusitis, Asthma And Colds - 04/29/2008
Scientists at Johns Hopkins have outlined a new path for potential therapies to combat inflammation associated with sinusitis and asthma based on a new understanding of the body’s earliest immune response in the nose and sinus cavities.