I was taking Nature's Way Turmeric, standardized for 95% curcumin, one pill, three times a day. It did nothing. Today I took 2 pills at once and it worked. Examine.com says you can take 3g/day [6 pills] and there is a lot of scholarly research that shows tolerance of much higher doses. No one knows long term effects, but they don't know long term effects of otc and Rx drugs either. So I'm alternating between Turmeric, acetaminophen and ibuprofen to thin out the possible risks.