Has biomarker been found?

[Aidan Walsh]

Bhupesh Presty just published an abstract some markers on his Twitter page link, one is depletion of natural IGM, heightened reactivated HSV-1 EBV & increased elevated Fibronectin in ME/CFS & Long COVID in med rXiv

No, and unlikely ever to have a single marker found. ME/CFS is partially generic (Genes) which was activated by environmental factors (epigenetics). ME/CFS is a basket that a lot of different conditions is dropped into.

See

Genetic association study in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) identifies several potential risk loci [2022]​

Autoimmunity-Related Risk Variants in PTPN22 and CTLA4 Are Associated With ME/CFS With Infectious Onset [2020]​

Fine mapping of the major histocompatibility complex (MHC) in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suggests involvement of both HLA class I and class II loci [2021]​

ME/CFS is actually 100% EDS

 

[Aidan Walsh]

Bhupesh Presty just published an abstract on some markers on his Twitter page link, one is depletion of natural IGM, heightened reactivated HSV-1 EBV & increased elevated Fibronectin in ME/CFS & Long COVID in med rXiv

 

[MarciaPDX]

I have been following Bhupesh Pruesty's research, and while he may have overstated the notion of finding a definitive biomarker, I wanted to at least have my fibronectin level tested, but can't find a lab that does this test. Does anyone know of a lab (in the US) that does this test?

 

[Aidan Walsh]

I have been following Bhupesh Pruesty's research, and while he may have overstated the notion of finding a definitive biomarker, I wanted to at least have my fibronectin level tested, but can't find a lab that does this test. Does anyone know of a lab (in the US) that does this test?

Maybe some kidney foundation would know, I think this ties to kidney failures in some

 

[MarciaPDX]

Maybe some kidney foundation would know, I think this ties to kidney failures in some

I will try that. Thanks.

 

[Woundedwarrior]

I hope the terms ME/CFS/Fibro actually drops completely dead...

His paper looks interesting, the review are mixed and he does seem to have made some progress. I have just heard him say on a video that the proposed diagnostic works for both ME and LC. The test is for fibronectin levels in the serum and a specific form of IgM which relates to the fibronectin, not IgM generally? That is as I understand it. One lab in Ireland is about to start offering the test, but as a paper just circulating on facebook reminds us there have been quite a number of potential markers identified but none have yet been sufficiently scaled up and tested on large enough cohorts yet. There are lots of issues in identifying a biomarker. but I do hope we will hear good news soon. It feels a bit exasperating hearing people saying ME is always EDS or CCI or uncle tom cobbly and all. It is a disease as recognised by a number of authorities and that is what we have to go on for now. I certainly know lots of people who don't have EDS but do have ME, and who have ME overlapping with other diseases such as MS and MG, or SLE. Autoimmune diseases tend to travel like London buses, in clusters both in individuals and in families. I recognise cfs is often used to refer to something broadly similar but which does not or does not quite meet the rigorous CCC or ICC diagnostic standard, often because of a less complex, or more fleeting (? less than 24 hours duration?) PEM. Others such as NICE use the terms to mean the same thing - ME as defined by the presence of the key symptoms including (any degree or form of) PEM. I don't know if that helps. I'm only able to go on what I've read, I'm not a doctor or a scientist, just a patient who has had this for 45 yrs.

Biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a systematic review
Maksoud et al. BMC Medicine (2023) 21:189 https://doi.org/10.1186/s12916-023-02893-9

RESEARCH ARTIC

BMC Medicine

Open Access

Biomarkers for myalgic encephalomyelitis/

chronic fatigue syndrome (ME/CFS):

a systematic review

1,2,3* 1,2,3 1,2 1,2 Rebekah Maksoud , Chandi Magawa , Natalie Eaton‐Fitch , Kiran Thapaliya and

Sonya Marshall‐Gradisnik1,2

 

[Aidan Walsh]

Biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a systematic review
Maksoud et al. BMC Medicine (2023) 21:189 https://doi.org/10.1186/s12916-023-02893-9

RESEARCH ARTIC

BMC Medicine

Open Access

Biomarkers for myalgic encephalomyelitis/

chronic fatigue syndrome (ME/CFS):

a systematic review

1,2,3* 1,2,3 1,2 1,2 Rebekah Maksoud , Chandi Magawa , Natalie Eaton‐Fitch , Kiran Thapaliya and

Sonya Marshall‐Gradisnik1,2

I sent the paper of Prusty to Garth Nicholson on his Facebook page you can read his response he believes what they are finding are actually leftovers.

I do not believe he thinks any cause with what they are looking at now & he was a microbiologist before, he knows his stuff no doubt & the former Chairman of MD Anderson Cancer Center & has published a lot of Scientific work. He is one honest person I would ask to review any published or online work

 

[Baz493]

Some researchers are now looking at the adrenal glands as a factor in long covid. https://www.nature.com/articles/s41574-022-00700-8 Because there is often localization of things like ACE2 in certain bodyparts researchers have been forced to identify specific regions of the body for higher levels of ACE2 in understanding which parts of the body are more vulnerable to the infection. https://www.frontiersin.org/articles/10.3389/fendo.2020.593179/full https://www.frontiersin.org/articles/10.3389/fmed.2020.594495/full

 

[Aidan Walsh]

Just in long Covid? Will read more later thanks Baz493

 

[Baz493]

Just in long Covid? Will read more later thanks Baz493

Not just long covid. I had previously looked at research connecting the flu with ACE2 and it's likely that there are actually many infections which can trigger this same effect. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378143/ This is an article linking the XMVR retrovirus with chronic fatigue syndrome. https://www.nih.gov/news-events/nih-research-matters/virus-linked-chronic-fatigue-syndrome

 

[Aidan Walsh]

Some researchers are now looking at the adrenal glands as a factor in long covid. https://www.nature.com/articles/s41574-022-00700-8 Because there is often localization of things like ACE2 in certain bodyparts researchers have been forced to identify specific regions of the body for higher levels of ACE2 in understanding which parts of the body are more vulnerable to the infection. https://www.frontiersin.org/articles/10.3389/fendo.2020.593179/full https://www.frontiersin.org/articles/10.3389/fmed.2020.594495/full

I have an enlarged left kidney, it is also lopsided they refer to these as Drome Dary Humps like a single Camel's Hump it was found on an ultrasound so I wonder if this could be linked or not? Also, I know some who have a tumor on the adrenal gland called an insulinoma, most of the time they are benign & successful Surgery is the cure-all in many...

 

[Baz493]

I have an enlarged left kidney, it is also lopsided they refer to these as Drome Dary Humps like a single Camel's Hump it was found on an ultrasound so I wonder if this could be linked or not? Also, I know some who have a tumor on the adrenal gland called an insulinoma, most of the time they are benign & successful Surgery is the cure-all in many...

I have been asking myself the same questions. I have had nephrotic syndrome for decades and suspect that my kidneys failed after I collapsed at work from heat stroke. Nephrotic syndrome and adrenal insufficiency can be related through an enzyme called sphingosine-1 phosphate. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070023/ None of the health issues which occurred at the time were investigated, as the company I worked for left me lying unattended on the factory floor, so it's difficult to prove these things in my own case. Issues with breakdown of sphingosine-1-phosphate might explain the people you mention with the insulinoma. https://pubmed.ncbi.nlm.nih.gov/33631318/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272099/ A huge part of the difficulty with medical investigations is the vast gap between the highly advanced medical research which can explain our conditions and the relatively dated tests which doctors have at their disposal to diagnose the conditions. I always tell friends that research is around thirty years ahead of what doctors have available to them.

 

[Aidan Walsh]

I have been asking myself the same questions. I have had nephrotic syndrome for decades and suspect that my kidneys failed after I collapsed at work from heat stroke. Nephrotic syndrome and adrenal insufficiency can be related through an enzyme called sphingosine-1 phosphate. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070023/ None of the health issues which occurred at the time were investigated, as the company I worked for left me lying unattended on the factory floor, so it's difficult to prove these things in my own case. Issues with breakdown of sphingosine-1-phosphate might explain the people you mention with the insulinoma. https://pubmed.ncbi.nlm.nih.gov/33631318/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272099/ A huge part of the difficulty with medical investigations is the vast gap between the highly advanced medical research which can explain our conditions and the relatively dated tests which doctors have at their disposal to diagnose the conditions. I always tell friends that research is around thirty years ahead of what doctors have available to them.

Not surprised by this, can they now test for this & is it treatable? I am Negative in Addison's disease testing, I respond to hydrocortisone Cortef 5mg or prednisone, thanks

 

[Baz493]

I was put on prednisone, for nephrotic syndrome, decades ago but it only had limited benefit. I since been able to connect my allergy to gluten with cadmium exposure. Cadmium binds to albumin, triggering the body to eliminate the cadmium via the renal tract and triggering albuminuria/nephrotic syndrome. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974692/ There are funny things which happen when you have high cadmium levels in the body. On the one hand the albumin binding weakens binding of other minerals so you wind up with zinc and iron deficiencies and high levels of oxidative stress. Cadmium also binds to HIZR1 receptors in the intestines, telling the body that there is an excessive level of zinc in the body even if the body is deficient. https://www.pnas.org/doi/10.1073/pnas.2022649118 Zinc deficiency is related to kidney disease and nephrotic syndrome. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112700/

 

[Aidan Walsh]

I was put on prednisone, for nephrotic syndrome, decades ago but it only had limited benefit. I since been able to connect my allergy to gluten with cadmium exposure. Cadmium binds to albumin, triggering the body to eliminate the cadmium via the renal tract and triggering albuminuria/nephrotic syndrome. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974692/ There are funny things which happen when you have high cadmium levels in the body. On the one hand the albumin binding weakens binding of other minerals so you wind up with zinc and iron deficiencies and high levels of oxidative stress. Cadmium also binds to HIZR1 receptors in the intestines, telling the body that there is an excessive level of zinc in the body even if the body is deficient. https://www.pnas.org/doi/10.1073/pnas.2022649118 Zinc deficiency is related to kidney disease and nephrotic syndrome. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112700/

so many causes, so hard to keep up each day yet everyone is sick still very frustrating overall

 

[Aidan Walsh]

Just checking...Has a biomarker been found that we can all get tested for in order to have documentation? Something standard that we can go to our own physician's clinic to have odered?

Like what test(s) are you thinking of Theresa now? xx hope u r ok xx

 

[Aidan Walsh]

I will try that. Thanks.

Let me know of any luck to be tested I am presently in the UK Southampton area now thanks xx I need a private lab here