any time I see the words 'We all know that exercise is important for a strong and healthy body', I get nervous... but this blog (by Francis Collins) is interesting. It talks about how the muscles secrete a certain protein that crosses the blood brain barrier and helps to make our brain better. that sounds like another thing possibly going wrong in PWME's bodies, doesn't it? Anyway, interesting read!
Researchers have assembled a growing body of evidence that suggests skeletal muscle cells secrete proteins and other factors into the blood during exercise that have a regenerative effect on the brain.
Now, an NIH-supported study has identified a new biochemical candidate to help explore the muscle-brain connection: a protein secreted by skeletal muscle cells called cathepsin B. The study found that levels of this protein rise in the blood of people who exercise regularly, in this case running on a treadmill. In mice, brain cells treated with the protein also exhibited molecular changes associated with the production of new neurons. Interestingly, the researchers found that the memory boost normally provided by exercise is diminished in mice unable to produce cathepsin B.