Pentazocine/Talwin for chronic pain?

[Remy]

In this age of the opioid epidemic, fibromyalgia and chronic pain patients are suffering. While I think that opioids ultimately do more long term harm than good by activating the microglial cells, I also think that pain medication in general has an important role in symptom management.

Reading through Tuning the Brain by Dr Goldstein again over the weekend, I came across an atypical opioid called Talwin/pentazocine that he apparently used with some great success.

Given that it does not work at the mu opioid receptor and has less potential for addiction or abuse, it is consequently Schedule 4 in the US which might make more doctors more open to prescribing it than the typical opioid.

Does anyone have any experience with using this drug to manage chronic pain?

From Reviving the Broken Marionette:

 

[GG]

So this sounds like the Naloxone part of the med, like Naltrexone does it seems. I realize the "one" word is used for narcotic antagonist agents.

https://www.vocabulary.com/dictionary/narcotic antagonist
Patients Receiving Narcotics

Pentazocine is a mild narcotic antagonist. Some patients previously given narcotics, including methadone for the daily treatment of narcotic dependence, have experienced withdrawal symptomsafter receiving pentazocine.

https://www.rxlist.com/talwin-nx-drug.htm

GG

 

[Remy]

So this sounds like the Naloxone part of the med, like Naltrexone does it seems. I realize the "one" word is used for narcotic antagonist agents.

https://www.vocabulary.com/dictionary/narcotic antagonist
Patients Receiving Narcotics

Pentazocine is a mild narcotic antagonist. Some patients previously given narcotics, including methadone for the daily treatment of narcotic dependence, have experienced withdrawal symptomsafter receiving pentazocine.

https://www.rxlist.com/talwin-nx-drug.htm

GG

Yeah, definitely the naloxone. My understanding is that it isn't even absorbed from the stomach though and is only included to keep people from using it IV.