Thread in hope it might help others

Baz493

Member
I think that the best way that I might be able to help others here is by gradually telling my own story about chronic fatigue.

Over twenty years ago, around a year after starting a new job, I began to experience chronic fatigue whenever I was away from work. When I started work each day I was still struggling but would begin to be filled with energy within the first hour and be filled with energy by the end of the work day. By the time I drove home I would be completely exhausted again and would go to sleep almost immediately, waking again in the morning ready to start work again. Every doctor I consulted just told me not to worry, drink lots of water, and get plenty of rest. That wasn't any help at all. Every bookstore I went into I searched for answers and, after a year, found what I was looking for. It was a secondhand book by Dr Ronald L Hoffman; Tired all the time. You know how used books often fall open to whichever page has happened to be opened most often? Well, it did. It was as though the book had been waiting in the store just for me. The open pages detailed a list of chemicals which trigger chronic fatigue and one leaped out at me; trichloroethylene. We sprayed the solvent all over the place at work, cleaning paint and oil off of metal moulds. It's the same chemical which had to be banned from use in the office product, White out, because it caused illness and fatigue in office workers. The company had to have special permission from the government in order to use the chemical but, because of self-regulation laws, couldn't be bothered with living up to the required standards for protecting workers who were using it. I recovered within weeks of doing everything I could to protect myself but the story didn't end there. Since it's a long story, I will try to detail things in subsequent posts on this thread.
 

Baz493

Member
Many years after the bout of chronic fatigue, resulting from the trichloroethylene exposure, I experienced another bout. Strangely, I have never been able to work out what triggered this one. So far as I was aware I hadn't been exposed to any toxic substances on this occasion. I consulted the book I mentioned but couldn't find any solutions so I went back to what I am familiar with; health and fitness. I joined my local gym and performed a single set of light, weighted, exercises before fatiguing and walking out. On my next visit, the next day, I was able to perform an additional repetition. I kept up this 'kaizen' approach to exercise for the subsequent year. I also commenced taking large doses of high quality antioxidants, oils, vegetable juices, and other supportive supplements, while improving my diet in any way I thought might help. It took a year before I realised, one day, that I had completely recovered from my chronic fatigue. While I found that Co-enzyme Q10, from my local health food stores, raised my energy levels slightly I quickly learnt that it was worth ordering Ubiquinol, a much stronger form of the enzyme, online.

In order to help you to understand the effect of trichloroethylene on chronic fatigue it is necessary to explain that it replaces a part of the Kreb cycle, initiating the tricarboxylic acid cycle of anaerobic respiration. As this cycle requires exposure to the chemical, in order to create energy, absence of the chemical robs the cycle of a key ingredient. The tricarboxylic acid cycle is often present in chronic fatigue, for a variety of reasons and I cannot hope to explain all of them.
 

Baz493

Member
Finally I come to event three. While this isn't actually chronic fatigue I will still include it just in case. Working in the glass industry I experienced two years of extremely intense workload with repeated exposures, without respiratory protection, to a cold end coating spray placed on the outside of bottles. It took me years to find out the actual name of the chemical, 3-aminopropyltriethoxysilane. During that time it, and the solvents used for aerosolisation, wrecked my respiratory function and burnt holes in my gastrointestinal tract. Since doctors, at least where I live, seem to know very little about industrial chemicals they diagnosed my condition as being completely psychological. I finally found a GP who helped me to run a huge number of tests for conditions which might explain the myopathy I experienced and one returned positive. I had PL-7 autoimmune antibodies. This got me in the door at the local hospital, which had previously refused me medical investigations and criticised me for claiming that anything was wrong with me. The antibodies were proof of a condition called myositis, an autoimmune myopathy which leaves you immensely fatigued. A lot of people who take statin medications wind up with this condition. The investigations which the result bought me proved acute respiratory failure and a range of health issues. For some reason my blood oxygen levels remain perfectly normal even though I have very little pulmonary function.

With the help of the wife of another myositis sufferer we put together these facts. Cellular oxidation, from excessive hydrogen molecules in cells, causes calcium flooding to try to soak up the hydrogen before it alters into lactic acid, lactate, or hydrogen peroxide. The calcium interferes with muscle function, which relies upon calcium flooding to trigger muscle contractions. Hydrogen peroxide releases arachidonic acid from cell membranes, triggering the formation of isoprostanes and isoprostane-like substances. These are going to really mess you up, if they occur, since they have hormone like effects and mess with ion channels inside cells. If you want evidence of chronic fatigue syndrome then try to get your physician to check your levels of F2-isoprostanes. These are linked to the condition in medical research. Of course they're also linked to so many other diseases that it might take a while for your physician to work out exactly what might be wrong with you.
 

Baz493

Member
There are very simple ways which I have found to reverse chronic fatigue, and other disease conditions. They won't cure anything but they will definitely help. Antioxidants, used for reversing oxidative states in the body, aren't equal. While vitamin C and E, and so on, are highly recommended by doctors and are necessary for reversing ill-health they are really pretty poor antioxidants. You can find the ORAC ratings for antioxidants on a huge number of different sites, each giving ratings on different foods. I've tended to use grape seed extract since it is fairly cheap, extremely effective, and readily available in large doses. That said, my brother turned out to be allergic to it, so give you may need to try something else if you are the same. For me, it turned the whites of my eyes from a dull greyish colour to bright white when I've used large doses. Restoring normal levels of calcium in cells requires the elimination of the oxidative state as well as force to push the calcium from the cells. That's why magnesium is necessary in the diet. Ideally this would come from green leafy foods but supplementation is often necessary. Do not take magnesium alone. I had a former naturopath who pushed me to take a magnesium only supplement with the consequence that I spent a couple of years fighting off repetitive leg cramps. Electrolytes need to be in balance with corresponding electrolytes. In the case of magnesium this is calcium. Ironic, I know, but you have to take 2 parts magnesium with 1 part calcium or you're likely to regret it. There are other electrolytes you can also use to help with the process of forcing out the calcium but magnesium is so essential to the cellular functions that it can't be replaced and the calcium flooding will result in it being forced out of the cells so it has to be replaced.

The reason that I have previously used exercise, in my own case weight training, in order to reverse chronic fatigue is that you need to get a good mixture of improvement in oxygenation, blood flows, muscle involvement in both of these, and so on, in order to magnify the effect of anything else that you are doing.

One final thing. Find out what caused your chronic fatigue. If you can't then you may still be being exposed to it. If so then you will continue to be poisoned by it. I could never identify the cause of my second bout of chronic fatigue; it may have been something which the company I worked for exposed us to or it may have been something which my local council tested as a weed killer for all I know. If it had been a permanent exposure then I probably would have been forced to find out what it was. Antioxidants, diet, and so on, are just band aid solutions if you are still receiving a toxic exposure. The book which I mentioned explains that you need to think of exposures like trying to carry bricks; one brick isn't too much of a burden but three are almost impossible to walk with. I had to eliminate gluten from my diet in order to get to my own peak performance, before the work exposure hit me like a brick wall. Oh, and companies lie; big surprise. The chemical I worked with was perfectly safe, until it wasn't. There are likely to be thousands of people who worked in the same job that I did who have varying degree's of the disability, fatigue, and illness, which I have experienced. When you experience chronic fatigue don't trust anyone's word; investigate every chemical you may be exposed to, whether directly or indirectly.
 

Baz493

Member
What to know about genes and how they can result in chronic fatigue. Don't get the idea that I know everything; I am far from that. However I have been able to learn about a few genes which influence the situation. The MTHFR gene mutation is probably the most discussed online since it can cause so many different diseases. It weakens a bond between folate and riboflavin which is required in the methylation processes of the body. These processes break apart molecules which have already been used so that the smaller molecules can be used in construction of new ones. The weak bond means that the necessary molecule falls apart before it can do the job. People with the mutation can't use synthetic folate; folic acid, so require natural methylfolate. They also require supplementation of the diet with riboflavin and vitamin B12, which is required in the bonding process.

Of less likely importance are the ACTN3 R577X genotype and the MLCK gene mutation, both of which influence muscle fatigue. People with these experience much faster muscle fatigue and reduced athleticism. The ACTN3 gene has been linked to the development of severe myopathy.

If anyone has questions or answers to the situation themselves I leave it to people to post them. I doubt whether I have much more that I can think of to post here but may be able to answer some questions which I haven't been able to think of as I've been writing these posts.
 

Baz493

Member
You probably haven't heard anyone mentioning this before but oils (lipids) can trainwreck your health and cause chronic fatigue and a variety of other diseases. And no, I'm not talking about LDL. When cellular oxidation occurs, due to the presence of excessive amounts of hydrogen, some of it is soaked up by the calcium which floods into cells in response to it. However, some will convert into lactic acid, lactate, and hydrogen peroxide. It's the last one which is of particular interest. When hydrogen peroxide damages cell membranes it releases arachidonic acid from the membranes. This acid is then free to attach to other lipids. These altered lipids are then known as isoprostanes. When it attaches to phospholipids they are known as isoprostane-like substances. These can not only weaken the integrity of any membranes in which they are incorporated but can also affect cellular ion channels due to their hormonal effects. They basically trigger anarchy within the cells, with inappropriate molecules entering places when they shouldn't. Your body basically begins to malfunction at the cellular level. This is going to be almost impossible for any physician to detect until many years after it has begun, since the condition may only result in traditionally recognised diseases after many years have passed. In the meantime the condition will likely be diagnosed as either psychosomatic or as chronic fatigue syndrome.
 

Baz493

Member
If you've ever experienced a severe health event then you may have had what occurred to me when I collapsed at work with heat stroke one time. Although my own case pivoted upon the heat-induced electrolyte imbalances there are all kinds of ways in which the same result can occur. What was important was the consequence. If you've ever noticed your urine turning a reddish brown colour then you may have thought it was blood, like I did. What it really was, in my own case, was evidence of muscle damage and the destruction of a protein which draws oxygen from the blood, myoglobin. The heat stroke basically caused such a severe oxidation event that it destroyed the myoglobin in my muscles leaving them starved of oxygen and unable to produce energy using aerobic respiration. Anaerobic respiration just isn't anywhere near as efficient for energy production and you wind up with chronic fatigue and myopathy.
 

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