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Amitriptyline Gets Mixed Report on Neuropathic Pain

The most common drug for neuropathic pain gets mixed review

  1. Cort
    Resource Type:
    Report or Study
    This Cochrane Report highlights how far we have to go in treating neuropathic pain. A tricyclic antidepressant, Amitriptyline line is one of the most commonly used drugs to treatment neuropathic pain (tingling, burning, etc. sensations).

    After analyzying fifteen authors concluded that there wasn't much good evidence that Amitriptyline was all that helpful. Many of the studies were small and poorly done. They acknowledged that the drug does help people - just not that many. (It's the same story with fibromyalgia drugs. Yes, they definitely help some people - not just nearly as many as one would want and not as much as one would want.)

    The fact that there is no supportive unbiased evidence for a beneficial effect is disappointing, but has to be balanced against decades of successful treatment in many people with neuropathic pain. There is no good evidence of a lack of effect; rather our concern should be of overestimation of treatment effect.

    Amitriptyline should continue to be used as part of the treatment of neuropathic pain, but only a minority of people will achieve satisfactory pain relief.