It turns out that opioid pain killers and simply being in chronic pain over time can reduce your hormonal levels - particularly testosterone and estrogen. Because hormones tend to reduce pain, reduced hormonal levels can increase your pain sensitivity.
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- Dr. Christina Lasich
In fact, the hormonal problem caused by opioids is called “opioid endocrinopathy”. It has been estimated that between 60-85% of those using opioids experience hormone suppression and associated symptoms like erectile dysfunction and sleepless nights. -