I have been suffering from ME for 19 years and 5 months. I was always curious why escitalopram and amisulpride help me despite the fact that I don't suffer from any mental disease. Now I found something interesting: 5HT-2A acts as a receptor for JCV. Amisulpride blocks this receptor and chronic use of SSRI desensitize and diminishes density of these receptors. Other medications that block this receptor include mianserin, risperidone and others.