Antihistamines for sleep

Discussion in 'Sleeping Better' started by Strike me lucky, Mar 2, 2016.

  1. Strike me lucky

    Strike me lucky Well-Known Member

    I use antihistamines to help sleep, usually for me its an add on to help sleep maintenance but doesnt help with initiating sleep for me.

    I alternate between different antihistamines just like i do benzos to help avoid tolerance.

    This is a list of sedating antihistamines i have used for sleep. Id be interested to hear from others and what they have used and experiences.

    Doxylamine 25mg first sleep aid i used and use to be very sedating but not so much since cfs and probably tolerance.

    Diphenhydramine 50 to 75mg

    Phenergan 25mg good for migraines

    Periactin 4mg also migraines

    Atarax 25 to 50mg

    Ketotifen 1mg

    Polaramine not that effective but might for others.

    They can all be good for other things other then allergies and sleep. They seem good for migraines, nausea and motion sickness.
    Who Me? likes this.
  2. Seven

    Seven Well-Known Member

    I have been on Trazadone (400mg to 50mg) to stay sleep and induce sleep I use Benadryl. I don't need the Benadryl so much anymore except I need it for allergies so I keep using it for that and since it makes me so sleepy I use it before bed.

    When trazadone does not work as well I go down (I know contrary to everybody else) then up after a few weeks and it works perfect I don't build tolerance.
    Strike me lucky likes this.
  3. Who Me?

    Who Me? Well-Known Member

    I use the active ingredient in Chlortrimeton as well as many that strike said. I swore by benedryl but it started to cause tachycardia.

    I also found Dramamine worked great for many years.

    @Strike me lucky you know if you addressed your oxidative stress you would be cured. Then you won't need all these things. Oxidative stress causes every problem known to man.
    Strike me lucky likes this.
  4. Veet

    Veet Well-Known Member

    I used a couple different antihistamines, Klonopin for a time. Then I switched to pituitary extract. which worked at least as well as any of the others, with no side effects.

    Maybe Oxidative stress amplifies every problem known to man.
    IrisRV, Strike me lucky and Who Me? like this.
  5. Who Me?

    Who Me? Well-Known Member

    And cats!

    Serum biomarkers of oxidative stress in cats with feline infectious peritonitis.
  6. Cort

    Cort Founder of Health Rising and Phoenix Rising Staff Member

    Interesting. Are there any that stand out for you - that work better than others?
  7. tatt

    tatt Well-Known Member

    I occasionally use chlorphenamine, usually with a glass of wine as that enhances the effect. Two glasses of wine and I might fall asleep before reaching the bed :) However I dont use it often as the sleep quality still isn't great.
    Strike me lucky likes this.
  8. Strike me lucky

    Strike me lucky Well-Known Member

    Of late periactin seems to improve sleep quality.
    There is some research saying in can help increase deeper stages of sleep and possibly enhance growth hormone levels.
  9. IrisRV

    IrisRV Well-Known Member

    Exactly the same for me!
    Who Me? likes this.
  10. Rosie26

    Rosie26 Active Member

    I wish I had of tried antihistamines years ago. I have recently been taking cetirizine 5mg most days and I am sleeping in an extra hour or two in the mornings. I used to wake up at 5-6am, now it is around 7am. This morning it was 7.45am which is a jaw drop for me. I am just going with it because I need catch-up sleep from all the years of insomnia I had.

    I think I might need to start experimenting though, and find others antihistamines so that I can do the alternating thing as well.
    I have a bottle of Benadryl that I have only taken a few sips of so far. Is it the cough mixture Benadryl the one you all talk about as Benadryl. I imagine it is and not a tablet?
    Strike me lucky likes this.
  11. Who Me?

    Who Me? Well-Known Member

    Try doxylamine and the active ingredient in chlortrimeton. can't think of the name right now. I think what @tatt said. I alternate those. They're pretty cheap. I also just ordered another one from overseas to try. Atarax?

    Benedryl caps are cheap. I used that for years but then it started to cause tachycardia.

    Also Dramamine. That'll knock you out but good.

    @Cort if you have epic insomnia like me, anthistamines are just another layer I add to sustain sleep. The only thing that initiates sleep for me is a benzo. I have a few I alternate.

    I've been having good luck with baicalin and oleamide. The oleamide is tricky to dose. Too much and you'll sleep great. And kiss most of the next day goodbye. Lol.
    Strike me lucky and Rosie26 like this.
  12. Rosie26

    Rosie26 Active Member

    I'll write those down, thanks, and see if I can get some of those OTC. I think I'll leave the Dramamine one out for awhile. LOL. I might end up waking around lunch with those ones. But handy to know about it for the future if needed.
  13. Paw

    Paw Well-Known Member

    I became wary of diphenhydramine -- which I used pretty regularly -- when I started reading about the risks of long term use of anticholinergics (namely dementia).

    At some point benedryl stopped working for sleep (at least at normal dosages), AND I thought MAYBE it was simultaneously causing more flu-like symptoms the next day. Maybe it was interacting badly with my attempts to boost acetylcholine during the day with supplements.

    Since Alzheimers seems connected to acetylcholine problems I'm inclined to remain wary of using diphenhydramine, at least regularly.
  14. Who Me?

    Who Me? Well-Known Member

    They're all OTC except the atarax.

    It's all about finding the dose that works but doesn't drug you out. I always wait till the weekend to experiment. Then I don't have to worry about dealing with M-F issues.
    Rosie26 likes this.