Antioxidants in Fibromyalgia

Cort

Founder of Health Rising and Phoenix Rising
Staff member
Every ME/CFS study that has assessed antioxidants has found them to be low. This FM study found high levels of Pla2 a phospholipase that produces among other things arachidonic acid which plays a role in inflammation.

Int J Rheum Dis. 2015 Nov 20. doi: 10.1111/1756-185X.12787. [Epub ahead of print]Plasma phospholipase, γ-CEHC and antioxidant capacity in fibromyalgia.
Fais A1, Cacace E2, Atzori L3, Era B1, Ruggiero V2.
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Abstract

OBJECTIVE:

Recent studies have suggested a possible role of high levels of plasma lysophosphocholines (lysoPCs) in fibromyalgia syndrome (FMS). The aim of this study was to evaluate the content of plasma phospholipases (e.g., Platelet Activating Factor Acetyl Hydrolase [PAF-AH], secretory Phospholipase A2 [sPLA2 ], Total Antioxidant Capacity [TAOC] and 2,7,8-trimethyl-2-(2-carboxyethyl)-6-hydroxy chroman [γ-CEHC]) in FMS patients and their association with clinical status and quality of life.
METHODS:

Thirty-six females meeting the 2011 American College of Rheumatology criteria for the classification of FMS and thirty-four healthy females were enrolled for the study. Plasma enzyme levels were quantified using commercial enzyme-linked-immunosorbent-assay (ELISA). In order to assess the disease severity and the functional status of patients, the Fibromyalgia Impact Questionnarie (FIQ) was used.
RESULTS:

Higher levels of sPLA2 and lower PAF-AH and γ-CEHC were observed in the plasma of FMS patients compared to the controls. A decrease in PAF-AH and TAOC levels were found in severe FMS (S-FMS) compared to mild/slight (MS-FMS) forms.
CONCLUSION:

The results of the study indicate a possible involvement of phospholipases and γ-CEHC in fibromyalgia syndrome.
© 2015 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.
 

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