It is thus very likely that arginine – with pKa 9.0 and 12,5- (and possibly other basic amino-acids - lysine, histidine, ornithine) defeats some viral activities by simply raising the pH of the membranes above a threshold pH where fusion of viral particles with the cellular membrane stops, thus limiting and preventing viral replication. The interplay between arginine and vitamin C is yet to be elucidated, but it is probable that vitamin C helps destroy the viral nucleic acids (both DNA and RNA) while they are freely circulating outside the cells and while their fusion with the cell membrane is being hindered by arginine's actions.
The doses we used for antiviral treatment were 3-5 g of arginine and 3-4 g of vitamin C divided in 3-4 daily administrations. The safety of such doses is very good, especially given the short treatment duration (up to 14 days of continuous administration). It is known from studies and clinical practice that arginine doses between 4-20 g are safely used in adults for cardiovascular conditions (angina pectoris, intermittent claudication, etc.) and even in premature infants up to 1 g/day was safely administered to prevent inflammation of the digestive tract.
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