Nucleotides are organic molecules that serve as the monomers, or subunits, of nucleic acids like DNA (deoxyribonucleic acid) and RNA (ribonucleic acid). The building blocks of nucleic acids, nucleotides are composed of a nitrogenous base, a five-carbon sugar (ribose or deoxyribose), and at least one phosphate group.
It is the building blocks of DNA and RNA (one nucleotide is one “unit” of a DNA or RNA strand). Our body needs tons of these any time a cell divides to make a new copy of DNA and when it makes proteins (proteins are responsible for pretty much everything that goes on in our body).
Nucleotides are the key to cellular regeneration designed to address the need of serious athletes and successfully tested by sportsmen and women in independent, high-intensity and endurance.
Our body creates nucleotides is synthesized using old proteins or ‘synthesis from amino acids’. What we eat contributes to how nucleotides are created. For example is glutamine and glucose. Food sources of nucleotides are found in food we can eat such as lamb, liver, mushrooms. However, not all fruit and other vegetables are rich in nucleotides.
Nucleotides are also found in human breast milk, which is important for growth of the baby taking it.
Humans adapt to dietary nucleotide intake by downregulating production
This means that if you are a healthy person, dietary nucleotides are probably not essential or important. However, when our body is sick, under extreme stress or poor diet, these dietary nucleotides becomes essential.
The production of nucleotides in our body when sick, optimizes the function of the gastrointestinal (villi comes alive) and boosts the immune systems.
Nucleotides Supplementation
Nucleotides are tiny building blocks of RNA and DNA, which are the blueprints for every cell in your body. Each of your trillion plus cells contains 6 billion nucleotides. These building blocks are stored in a very limited quantity in your liver. Trauma, surgery, immune challenges and other stresses can rapidly deplete the body’s stores of nucleotides. When depleted, rebuilding critical supplies of nucleotides to meet the body’s demands can take several days, if not weeks.
Supplemental nucleotides has four elements:
1. Ribonucleotides
2. Cytidine Monophosphate (CMP)
3. Uridine Monophosphate (UMP)
4. Adenosine Monophosphate (AMP)
5. Guanosine Monophosphate (GMP)
Nucleotides are fundamental nutrients like minerals which must be supplied from outside the body. They are found most abundantly in human breast milk. No other mammal has nearly
the concentration that is found in human breast milk. Nucleotides in breast milk are essential to a baby’s developing immune system. When breastfeeding isn’t possible, a nucleotide-enriched formula is recommended.
For young, healthy people, getting enough nucleotides from food may be possible, but as we grow older, this pathway becomes less efficient and our ability to absorb nucleotides decreases. Therefore, nucleotides in supplement form can provide an excellent solution.
Benefits of Oral Nucleotides Supplement
1. Boost your immune system
Nucleotides have important effects on the growth and development of cells which have a rapid turnover, such as those in the immune system and the gastrointestinal tract. Dietary nucleotide improves markers of immune response to strenuous exercise under a cold environment. Nucleotides help gut mucosal defense, which is also part of the immune system.
2. Repairs the Intestines
Nucleotides enhance intestinal repair after injury (alcohol, gluten, casein, others).
Animal work shows that villi height and crypt depth in the intestine is increased as a result of dietary nucleotides. This should increase nutrient absorption. Dietary nucleotides enhance the intestinal absorption of iron. They have been found to promotes healing of small bowel ulcers in experimental ulcerative ileitis.
They also help in the prevention and treatment of the injurious effects of NSAIDs (aspirin, ibuprofen)
3. Nucleotides Enhances Learning
In rats, dietary nucleotides increase phosphatidylcholine, phosphatidylethanolamine, DHA and arachidonic acid in the cerebral cortex. These rats were found to have enhanced learning.
4. Nucleotides May Help Prevent Cancer
Nucleotide deficiency promotes genomic instability in early stages of cancer development. Chromosomal instability in early cancer stages is caused by stress on DNA replication.
Nucleosides rescued the replication stress and DNA damage and dramatically decreased cancer-induced transformation.
5. Nucleotides May Help Irritable Bowel Syndrome
Irritable Bowel Syndrome (IBS) is a chronic disorder affecting an estimated 15 – 22% of western populations. Animal work shows that villi height and crypt depth in the intestine is increased as a result of dietary nucleotides.
Dietary nucleotides may be semi-essential under conditions of ill-health, poor diet or stress. Dietary nucleotide supplementation improves some of the symptoms of irritable bowel above baseline and placebo level.
6. Nucleotides Extends Life Span in a “rat experiment”
A 2013 study found that nucleotides in relatively low dosages, dose-dependently inhibits the age-related decrease in the activities of antioxidant enzymes and the age-related increase in the levels of oxidation product in both sexes. Compared to the control group, the incidence of death from tumors was decreased in both sexes.
Various experiments were done on Nucleotides but there are few website that have made a
comprehensive reviewon how Nucleotides fares in truly boosting a person’s immunity and treating disorders mentioned.
Side Effects of Nucleotides Supplementation
Some have reported stimulating effects of Nucleotides but with sedating side effects.
![ME/CFS lecture | Dr Nancy Klimas | 2011 [Chronic Fatigue Syndrome / SEID / New Zealand] - YouTube](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
