This is a great post on how brain fog is most likely caused by a combination of mast cell and glial activation...and may be fixed by a combination of a galantamine to activate the cholinergic pathway and ibudilast (currently one of the drugs Dr Younger is studying).
[bimg=no-lightbox]http://i1.wp.com/www.frontiersin.org/files/Articles/147642/fnins-09-00225-r2/image_m/fnins-09-00225-g001.jpg?resize=680%2C459[/bimg]Brain fog is a non-scientific term describing a set of symptoms including forgetfulness, impaired thinking, difficulty focusing, cloudiness, mental fatigue, spaciness, etc. R
Is brain fog purely subjective?
No. Some patients reporting the symptoms of brain fog have measurable cognitive deficits in working memory, speed/efficiency of processing, reaction time, attention, and concentration. R
Although there are MANY possible causes (which I will discuss in detail in future posts), the number one culprit is most likely 1) excessive mast cell/glial cell activation which 2) increases inflammation which 3) causes excessive histamine release in the hypothalamus which 4) activates histamine H3 autoinhibitory receptors which 5) causes brain fog. R