I have been looking at a ton of research connecting nickel allergy to a variety of health issues and happened to find this 2001 Swedish article, describing a connection between nickel allergy and chronic fatigue in women. https://melisa.org/wp-content/uploa...ty-of-Women-with-Chronic-Fatigue-Syndrome.pdf The article describes these issues resulting from exposure to either cigarette smoke or dietary intake however I was previously looking at factors involved in coeliac disease as being a potential cause of raised levels of nickel in the body. Early symptoms of nickel allergy often develop in skin and hair, with conditions like dermatitis and eczema resulting but also things like hair loss. The nickel binds to filaggrin in the top layers of the skin, disrupting the integrity of the skins surface and permitting entrance of infections. The body responds with neutrophils which attempt to eliminate foreign substances and organisms with serine proteases. These enzymes lead to further breakdown of tissues and hair, particularly if you have specific sets of genes which either lead to failure of serine protease inhibition by the body, such as mutations in the SPINK genes, or which make tissues more vulnerable to serine protease enzymes.