I took it for awhile when my POTS was so bad. It helped the tacky but contributed to what I think made my kidney function worsen. I had severe edema with it. And it made me so tired I could barely function. If I have a really bad tacky day and mast cell meds doesnt correct it, I keep it on reserve. But I find that either the mast cell meds or Tramadol with Bentyl work better for me. My thoughts were, I was tired of being tired on it.