'Corydalis yanhusuo extract for use as an adjunct medicine for low to moderate chronic pain'


This is an herb that is often used in Traditional Chinese Medicine (TCM)...it interests me because it says it works well for neuropathic pain too which is often very resistant to treatment.

Apparently it does not build tolerance either...so that is a great benefit of the herb as well. It's a dopamine receptor blocker which is interesting because I think typical opiate pain meds increase dopamine.

There are a few available on Amazon but I don't recognize the brands. I think if I try this one, I'll probably buy it from one of the stores where I purchase high quality Chinese herbs.

Most notably it can reduce chronic neuropathic pain which is poorly treated with common medicines. They also show that YHS seems to not lose its potency over time, as happens with many analgesics. Study results appear in one open-access online journal, PLOS ONE.

The researchers analyzed YHS pain relief properties in mouse tests that monitor acute, persistent inflammatory and chronic neuropathic pain, respectively, while in vitro tests revealed its mechanism of action as a prominent dopamine receptor blocker. Interestingly, in mice that have no dopamine D2 receptor, YHS effect is weakened in neuropathic pain.

Dopamine is an important neurotransmitters that when released from nerve cells to send signals to other nerves. It is known to be involved in reward but studies have also shown that dopamine may play a role in maintaining chronic pain, and that removing dopamine-containing cells can reduce this pain.

Additionally, the researchers found that YHS use did not lead to tolerance. They administered YHS four times over a seven-day period and measured the mice responses in acute pain, noting that YHS kept its potency while morphine lost its.

Since YHS is a dietary supplement commercially available in the United States, Civelli suggests that it might be an adjunct medicine for alternative pain treatment. "YHS is not a highly potent medicine when compared to morphine," he said. "But I would propose that it can be used for low to moderate chronic pain."
Story Source:
The above post is reprinted from materials provided by University of California, Irvine. Note: Content may be edited for style and length.
Journal Reference:
  1. Lien Wang, Yan Zhang, Zhiwei Wang, Nian Gong, Tae Dong Kweon, Benjamin Vo, Chaoran Wang, Xiuli Zhang, Jae Yoon Chung, Amal Alachkar, Xinmiao Liang, David Z. Luo, Olivier Civelli. The Antinociceptive Properties of the Corydalis yanhusuo Extract. PLOS ONE, 2016; 11 (9): e0162875 DOI: 10.1371/journal.pone.0162875


Well-Known Member
I just ordered a bottle of Corydalis by Parker from Amazon...I've been using White Willow Bark and 1 Ibuprofen and 1 OA Tylenol every 6 hrs give or take for the OA and FM issues. I believe my issue is far more OA than FM...but it's all connected.

Has anyone had success with the Corydalis?

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