Hi everyone, I was wondering if someone could explain to this poor brain-fogged person what the difference is between the ME/CFS research the NIH is doing (which seems to involve looking at hundreds of variables to see where the problem lies) and what the Open Medicine Foundation is doing (which seems to involve looking at hundreds of variables to see where the problem lies). I applaud both organizations for the work they're doing to solve this thing, but I don't understand where they're different from each other in what they're studying.
Great question. There are actually quite a few differences even in the immune section....This is worthy of short blog actually and I think I will do one...some of them we don't know because the NIH study hasn't released exactly what they are doing.
I remember Ron saying the two studies are very different.
Off the top of my head
Davis - more molecular profiling I believe, more gene and genetic analyses, deep examination of the mitochondria, more comprehensive (maybe) examination of the immune system, deeper examination of viruses, heavy metals,
NIH - before and after exercise test! deeper examination of the autonomic nervous system, two kinds of brain scans, an overnight stay in a chamber that examines energy metabolism, examination of 1500 immune and other factors, implanting immune system in mice, neuron work outside the body which I don't understand at all..
OMF Severe Patient Big Data Study
Research Tests
- RNA Gene Expression – PBMCs
- RNA Gene Expression – NKs
- RNA Gene Expression – Monocytes
- RNA Gene Expression – T-Cells
- RNA Gene Expression – B-Cells
- RNA Gene Expression – Macrophages
- RNA Gene Expression – Dendritic Cells
- MicroRNA in Plasma
- Proteomics
- Cell-Free DNA
- Whole Genome Sequencing
- Whole Exome Genome Sequencing
- Mitochondrial Genome Sequencing
- Mitochondrial DNA/Nuclear DNA Radio
- HLA DNA Sequencing
- WBC density
- Autoantibody panel
- T-cell Repertoire DNA Sequencing-Stanford
- T-cell Repertoire DNA Sequencing-Sequenta
- CyTOF Standard Panel
- CyTOF Additional Panels
- Pan Viral Panel
- Serum Cytokines
- Ceres Nano Lyme
- Microbiome – stool
- Metabolomics – stool
- Metabolomics – plasma
- Metabolomics – urine
- Heavy Metals – blood
- Heavy Metals – urine
- Mycotoxins by Magarray
Clinical Testing
- Acylcarnitines
- Ammonia
- Bartonella extended cx
- Biotin (Vitamin B7)
- CBC (Complete Blood Count)
- Chemistry Comprehensive Panel
- Creatine Kinase
- Copper
- C- Reactive Protein
- Cysteine
- Folate
- FSH (Follicle-Stimulating Hormone)
- LH (Luteinizing Hormone)
- Estrogen
- HbA1C (Hemoglobin A1c)
- Homocysteine
- IgG Subsets
- Lactate
- Lyme Serology with reflex Western Blot
- Lymphocyte Subsets
- MMA (Methylmalonic Acid)
- MTHFR Mutations (Methylenetetrahydrofolate)
- Natural Killer Cell (Count & Function)
- Organic Acids – urine
- Pyruvate
- Serotonin
- Testosterone
- Thyroid Panel
- Uric Acid
- Vasopressin/ADH
- Viral Digital PCR
- Viral Serologies:
- EBV EA (Epstein Barr Virus EA)
- EBV NA (Epstein Barr Virus NA)
- EBV VCA (Epstein Barr Virus VCA)
- CMV (Cytomegalovirus)
- HHV-6 (Human Herpesvirus 6)
- Parvovirus
- HHV-7 (Human Herpes Virus 7)
- HSV1&2 (Herpes Simplex 1 & 2)
- Vitamin B12 (Cobalamin)
- Vitamin D25 OH
Other Testing/Monitoring
- Extended EEG
- Sleep monitoring
- Fitbit
- Cognitive Testing
- Questionnaires – SF36, PROMIS
NIH
http://mecfs.ctss.nih.gov/index.html