Yes there are medications and supplements that help with ME. The problem is that each one works for a few individuals, doesn't help others, and makes some worse, and there's no way to tell in advance which ones will work for which individuals. Also, some will work for a few doses, then stop working and never work again; that's sadly common with ME.
In my 20+ years of ME, I've found three treatments that worked really well for me ... but haven't been that effective for anyone else. I've found several more that either cured a symptom or just blocked it for a few months before the problem went away for some other reason (too hard to prove what worked). I've also found a few treatments that worked briefly, but then stopped working. Of course, I also found plenty of things that made me feel worse; luckily none had long-term negative effects.
I see trying treatments for ME as buying tickets in a lottery: there's only a tiny chance that you'll win, but not buying any tickets means that you're guaranteed to never win.
I'd also like to point out that only one of my effective treatments was a prescription drug (LDN). The other two very effective ones were already in my kitchen (cumin and iodine). You can spend a lot of money trying really expensive pharmaceuticals, but I think you're just as likely to find an effective treatment with some cheap things from your local grocery store. A randomly-selected bottle of herbs or spice might be just as likely to help as a $100k six-month antiviral treatment.
One more point: pay attention to changes in your symptoms. If you feel a bit better some day, try to figure out what might have been responsible. A food/activity/symptoms journal is important for this, since human memory is so fallible. Cumin might have been an effective PEM blocker for me for years, but it wasn't until I noticed that some expected PEM (after chainsawing wood) didn't show up that I could check my journal for what might have caused it, and doing intentional experiments to prove what the factor was.
Next time you're shopping for food, look at some food (or herb or spice or whatever) and wonder whether it might be your winning lottery ticket.