Drinking aloe vera has always worked well for me. It calms me down and smooths me out. It's not huge but its definitely noticeable. I like it a lot. I get the $6.99 gallon bottle (an entire gallon!) from Trader Joe's. It's probably not particularly good so far as aloe vera goes but it works just fine for me and its surprisingly affordable. It lasts me about a week. I have no idea why it has this affect on me though....I've never heard of it for use in ME/CFS.