Do you realise that heart and circulatory disease is caused by inflammatory processes caused by Increased Digestive Permeability? Anything which dampens inflammation is helpful like antioxidants such as Vit E, Vit C, NAC ->glutathione and sulfur like MSM which spares the sulfur amino acids such as cysteine from being converted to sulfur which the body needs. There are herbs which can block the effects of LipoPolySaccharides (LPS) which enter the bloodstream in the colon from the cell walls of gram negative bacteria. LPS is highly inflammatory and is used in research to promote inflammatory processes.
Any herbs which can help these processes such as Milk Thistle extract for glutathione and other natural antioxidants can be helpful.
Cordyceps mushroom can be very helpful because it lowers inflammatory markers ie cytokines as well as having anti-fatigue effects. There are extracts which indicate their polysaccharide content which is a false idea because most of the polysaccharides in them comes from the substrate they are grown on which has no beneficial effect. It is the Beta Glucans which are helpful and which needs to be watched out for. One product proudly declares that it has 30% polysaccharides of which 10 to 15% is Beta Glucans which works out to be only 3% to 4.5% Beta Glucans by weight. The extract that I recently purchased has 25% Beta Glucans which is a significantly higher concentration. Stephen Harrod Buhner recommends large amounts of Cordyceps ie 50 grams to have a significant effect. One or two capsules just does not compare. I am up to 3 grams at a time of a Cordyceps extract with 25% Beta Glucans. I am being careful not to increase it too fast because the previous Cordyceps that I was using which had 30% polysaccharides tended to make me sleep whenever I had too much. I think the problem was actually due to hydrolysed collagen and not the cordyceps. Hydrolysed collagen is not all peptides because there are some proteins still remaining which my body/immune system reacts badly to. Either that or the large amount of glycine is just too much for me and makes me sleep, but even small amounts of collagen has the same effect so I doubt that it is glycine TBH. I can take 5ml of Glycine powder without any problems.
A good guide on Cordyceps:
https://hackspirit.com/cordyceps/