Okay, does anyone have their lactate dehydrogenase values? My enzyme values are consistently 60 to 70 per cent of normal. This enzyme quantity is under strict genetic control. Lack of LDH is one of the several glycogen storage disorders - number 11, I believe. Very little research.
LDH converts lactate to pyuvate and back, as well as NAD+ to NADH and back. The pyruvate is then chemically converted to several possible compounds, which then enter the citric acid cycle, where we get our big ATP production. When oxygen is in short supply, LDH converts pyruvate to lactate, with a small amount of energy production. Of course, this is a self limiting process, as lactate builds in tissues.
It is interesting that red blood cells have no mitochondria, and depend on LDH 1 ( these are 5 main isoenzymes for LDH) to convert pyuvate to to lactate, which yields some energy. The red blood cells use none of the oxygen they carry. Thus, could an LDH deficiency affect red blood cell activity ? No research on this that I have found.
So, LDH -1 is of critical importance to red blood cells and their activity. Mitochondria are not even involved.
Parvoviruses ( like B19 - which I have) can infect the precursor cells to mature red blood cells, and cause some anemia.
The biochemical apparatus is so complex that it takes research experts to address the possibilities.
@Merida does your LDH deficiency affect your large muscles (LDHA) or your heart(LDHB)?
I think I have seen some people develop rhabdomyolysis from taking statins. I am not suggesting that LDH deficiency is the same thing, but just very interesting that one can get the same problem through a different pathway. Statins affect the mevalonate pathway and affect production of heme, cholesterol, and one other thing that I can't remember. But I am now wondering if the LDH deficiency and statins both affect Complex IV through heme deficiency??
This is what it says about LDHA: "During the anaerobic phase of glycolysis (the Cori Cycle), the mutated enzyme is unable to convert pyruvate into lactate to produce the extra energy the cells need. Since this subunit has the highest concentration in the LDH enzymes found in the skeletal muscles (which are the primary muscles responsible for movement), high-intensity physical activity will lead to an insufficient amount of energy being produced during this anaerobic phase. This in turn will cause the muscle tissue to weaken and eventually break down, a condition known as rhabdomyolysis."