fatigue biomarker found showing difference between CFS and regular fatigue

bobby

Well-Known Member
I'm not sure I'm understanding the details of this. Apparently they're saying HHV-6 and HHV-7 can be used as biomarkers. Sounds promising?
Researchers in Japan measured salivary human herpesvirus HHV-6 and HHV-7 and found they can be used as biomarkers to tell the difference between physiological (recovers with rest) fatigue and pathological fatigue.
https://meaustralia.net/2016/08/12/japan-fatigue-biomarkers-show-difference-between-chronic-fatigue-syndrome-and-ordinary-fatigue/

full paper here: http://www.sciencedirect.com/science/article/pii/S0006291X16311251
 

Cort

Founder of Health Rising and Phoenix Rising
Staff member
I'm not sure I'm understanding the details of this. Apparently they're saying HHV-6 and HHV-7 can be used as biomarkers. Sounds promising?


https://meaustralia.net/2016/08/12/japan-fatigue-biomarkers-show-difference-between-chronic-fatigue-syndrome-and-ordinary-fatigue/

full paper here: http://www.sciencedirect.com/science/article/pii/S0006291X16311251
Well that is just very frigging interesting particularly since HHV-6 and HHV-7 were NOT increased in ME/CFS or those other disorders. They are not a biomarker for ME/CFS or those diseases but they could indicate when fatigue is just fatigue..

HHV-6 reactivation is not associated with fatigue in ME/CFS - interesting.

What a great study design by the way! These are the kind of studies that we need.

(I wish they had measured more things...)
 

bobby

Well-Known Member
@Cort so if I understand correctly, they're saying that these are markers of fatigue caused by an underlying illness process (of any illness), and not just fatigue in the sense of a natural bodily process?
 

Cort

Founder of Health Rising and Phoenix Rising
Staff member
@Cort so if I understand correctly, they're saying that these are markers of fatigue caused by an underlying illness process (of any illness), and not just fatigue in the sense of a natural bodily process?
Actually I think it's the opposite. HHV6 and 7 naturally reactivate in healthy people but not in people with these illnesses. It's a weird finding....Why would they not reactivate in ME/CFS? At the very least you would think they would be reactivated as much as in healthy controls unless there's something weird about these viruses in ME/CFS.
However, HHV-6 and HHV-7 did not increase in obstructive sleep apnea syndrome (OSAS), chronic fatigue syndrome (CFS) and major depressive disorder (MDD), which are thought to cause pathological fatigue. Thus, HHV-6 and HHV-7 would be useful biomarkers for distinguishing between physiological and pathological fatigue.
 

Seven

Well-Known Member
That is the opposite of CFS definition in USA, hh6 is a common reactivation in CFS (high number of patients) me included. I have not being able to suppress hh6, and when my NK numbers and activities were low. My activity is ok now (4 years of treatment) but numbers are still low and hh6 is still active.
 

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