Remy
Administrator
Looks like the metabolic disease, T2 diabetes, is also modulated by acetylcholine and the vagus nerve. Many of us struggle with higher than *should be* blood glucose despite an excellent diet and intractable weight gain. Maybe this is part of the reason why...and maybe galantamine can offer some relief?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532414/
Galantamine is available as an rx or OTC supplement, strangely enough. It's typically used for Alzheimer's disease though the relevant applications may be much more widespread.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532414/
Galantamine is available as an rx or OTC supplement, strangely enough. It's typically used for Alzheimer's disease though the relevant applications may be much more widespread.
The cholinergic anti-inflammatory pathway is one of the putative biochemical pathways that link diabetes with Alzheimer disease. Hence, we aimed to verify the potential antidiabetic effect of galantamine, unveil the possible mechanisms and evaluate its interaction with vildagliptin.
The n5-STZ rat model was adopted and the diabetic animals were treated with galantamine and/or vildagliptin for 4 weeks.
Galantamine lowered the n5-STZ-induced elevation in body weight, food/water intake, serum levels of glucose, fructosamine, and ALT/AST, as well as AChE in the tested organs. Moreover, it modulated successfully the lipid profile assessed in serum, liver, and muscle, and increased serum insulin level, as well as % β-cell function, in a pattern similar to that of vildagliptin.
Additionally, galantamine confirmed its antioxidant (Nrf2, TAC, MDA), anti-inflammatory (NF-κB, TNF-α, visfatin, adiponectin) and anti-apoptotic (caspase-3, cytochrome c) capabilities by altering the n5-STZ effect on all the aforementioned parameters.
On the molecular level, galantamine/vildagliptin have improved the insulin (p-insulin receptor, p-Akt, GLUT4/GLUT2) and Wnt/β-catenin (p-GSK-3β, β-catenin) signaling pathways.
On almost all parameters, the galantamine effects surpassed that of vildagliptin, while the combination regimen showed the best effects.
The present results clearly proved that galantamine modulated glucose/lipid profile possibly through its anti-oxidant, -apoptotic, -inflammatory and -cholinesterase properties. These effects could be attributed partly to the enhancement of insulin and Wnt/β-catenin signaling pathways.
Galantamine can be strongly considered as a potential antidiabetic agent and as an add-on therapy with other oral antidiabetics.