High Ammonia levels

[grasta de burcha]

I came across an article somewhere re this lab test result. Pretty sure it was on Health Rising. Would appreciate if anyone can point me in a direction to locate it.

 

[Baz493]

I don't know whether it's relevant to your question but pathogenic bacteria in our microbiome produce ammonia. They seem to do this to trigger our bodies, which respond to the ammonia, to produce an enzyme called N-acylethanolamine. This enzyme hydrolyses (breaks down) various fatty acid ethanolamides. The primary known consequence of this is the breakdown of palmitoylethanolamide (PEA). PEA can be found in certain foods and supplements but is also produced by healthy bacteria in our microbiomes. They produce it because it helps to kill the pathogenic bacteria as well as feed other good bacteria. Hence the pathogenic bacteria having developed the mechanism of ammonia release so that our bodies break it down. Have enough PEA in our gastrointestinal tract and you maintain a healthy microbiome and have low levels of ammonia.

 

[Carl#1]

It might also be worth testing for Ammonia production in your stomach which is a very common problem. Helicobacter Pylori is the best known and strongest Urease producing bacteria which infects the stomach. There are also other pathogens which can also make Urease in order to neutralize acid by producing Ammonia because Ammonia has a high pH which neutralizes acid & also producing carbon dioxide producing a burp.

If you try drinking something acid like lemon juice or vinegar and swallow that with some saliva which contains urea it can provide a very simple test for Urease. Then if you burp then there is a fairly high chance that you have a Urease positive micro-organism in your stomach that is adversely affecting your stomach function and poisoning your body with Ammonia. It also stops the protective function of the stomach from working correctly.

Additional information:
Palmitoylethanolamide (PEA) serves several important purposes in the human body:

1. Anti-inflammatory action: PEA acts as an endogenous anti-inflammatory compound, helping to reduce inflammation throughout the body[1]. It inhibits the release of pro-inflammatory mediators from mast cells and other immune cells.

2. Pain modulation: PEA has analgesic properties and helps reduce pain perception. It acts on multiple targets involved in pain signaling, including TRPV1 channels[1][4].

3. Neuroprotection: PEA exhibits neuroprotective effects, potentially helping to protect neurons from damage and degeneration[1][3]. This may be relevant for neurodegenerative conditions.

4. Immunomodulation: PEA modulates immune system activity, helping to regulate immune responses[1].

5. Homeostatic regulation: PEA is produced on demand within cell membranes in response to cellular stress or injury, acting as a pro-homeostatic protective response[1].

6. Allergy management: PEA has shown benefits in managing allergic reactions by inhibiting mast cell activation[1].

7. Mood and sleep regulation: Some evidence suggests PEA may have positive effects on mood and sleep quality[1].

8. Cardiovascular health: PEA may help regulate blood pressure and vascular function through its effects on endothelial cells[4].

9. Glaucoma management: PEA has shown potential in reducing intraocular pressure in glaucoma[4].

10. Skin health: PEA has demonstrated benefits for skin conditions like atopic eczema when applied topically[4].

In essence, PEA acts as an endogenous protective and regulatory compound, helping to maintain balance in various physiological systems, particularly in response to stress, injury, or disease states.

Citations:
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157570/
[2] https://www.webmd.com/vitamins/ai/ingredientmono-1596/palmitoylethanolamide-pea
[3] https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.00821/full
[4] https://en.wikipedia.org/wiki/Palmitoylethanolamide
[5] https://www.mdpi.com/2673-9879/3/4/58
[6] https://www.lambertshealthcare.co.uk/other-nutrients/palmitoylethanolamide-pea/neurological/
[7] https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-018-0934-z
[8] https://www.ncbi.nlm.nih.gov/books/NBK526069/