Histamine - not all receptors are addressed

Who Me?

Well-Known Member
I've seen several things lately that say taking antihistamines for mast cell is maybe not the best thing. This is just a small piece. I know I'm in way more pain lately and my brain is a mess.

Unfortunately, the receptors commonly not addressed with meds, H3 and H4, are the ones responsible for (among other things) modulating pain [3] and our mast cells/immune system [4], respectively, which explains why many people with histamine issues and mastocytosis still suffer from debilitating bone pain, depression, immune system dysfunction and others, in part (in my opinion) because they are not lowering their overall histamine burden – they’re relying on antihistamines to do the job for them. But of course antihistamines open the appetite [5], leading to more histamine roaming the body causing damage, except a little less damage to the H1 and H2 receptor areas. So you feel less respiratory and gastric issues (maybe) and are encouraged to eat “normally”, use cosmetic products like nail polish that are mast cell degranulation/histamine triggers [6], but continuing with life as you know it, learning to live with the fall out of flooding your H3 and H4 receptor controlled areas (pain and immune system), which then leads to more dysfunction and pain!
http://thelowhistaminechef.com/tag/anti-inflammatory-foods/

@Cort I thought you were going to make a histamine/mast cell forum?
 

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