Two recent studies prompted Dr. Holtorf to do a blog recommending CoQ10
CoQ10 Can Reduce Fibromyalgia Pain, Fatigue and Morning Stiffness
"The first study, conducted by researchers and reported in the Journal Antioxidants and Redox Signaling, sought to measure the effects of CoQ10 supplementation on adult patients with fibromyalgia. The researchers noted that both mitochondrial dysfunction and CoQ10 deficiency have been implicated in fibromyalgia pathophysiology.
In the study, patients who were given 300 milligrams (mg) of CoQ10 daily for 40 days saw reductions in pain, fatigue, morning stiffness and tender points. Other positive findings included recovery of inflammation, improvement of antioxidant enzymes, and an increase in the ability of the mitochondria to regenerate. Mitochondria are responsible for cellular energy production. AMPK gene expression levels also recovered in the patients given CoQ10 treatment. Notably, one of the AMPK enzyme functions is to instruct mitochondria to switch from using energy to producing energy.
The researchers have previously studied the link between mitochondrial dysfunction, oxidative stress and inflammation in fibromyalgia. Based on the study results, they concluded that CoQ10 could be part of an effective therapy for fibromyalgia."
Holtorf recommends the ubiquinol form:
"CoQ10 comes in two forms – ubiquinol, the active antioxidant form, and ubiquinone, the oxidized form, which the body partially converts to ubiquinol. Many multi-ingredient supplements contain both forms, however, ubiquinol has greater antioxidant efficiency than the ubiquinone form."
Another study:
"In Redox Report, researchers looked at increased oxidative stress and CoQ10 deficiency in juvenile fibromyalgia patients. Lab tests conducted at the beginning of the study showed that children with fibromyalgia had significantly decreased serum plasma levels of ubiquinol, and a significantly increased ratio of ubiquinone (oxidized CoQ10) to total CoQ10, compared to healthy controls, suggesting that fibromyalgia is associated with CoQ10 deficiency and increased oxidative stress, according to the researchers.
Next, the researchers supplemented the children with 100 mg per day of ubiquinol-10 for 12 weeks. The patients saw significant improvements in chronic fatigue scores, as well increased Co10 levels and decreased ubiquinone levels. The researchers concluded that CoQ10 status may be impaired in subjects with juvenile fibromyalgia and that supplementation with CoQ10 may be of benefit."
CoQ10 Can Reduce Fibromyalgia Pain, Fatigue and Morning Stiffness
"The first study, conducted by researchers and reported in the Journal Antioxidants and Redox Signaling, sought to measure the effects of CoQ10 supplementation on adult patients with fibromyalgia. The researchers noted that both mitochondrial dysfunction and CoQ10 deficiency have been implicated in fibromyalgia pathophysiology.
In the study, patients who were given 300 milligrams (mg) of CoQ10 daily for 40 days saw reductions in pain, fatigue, morning stiffness and tender points. Other positive findings included recovery of inflammation, improvement of antioxidant enzymes, and an increase in the ability of the mitochondria to regenerate. Mitochondria are responsible for cellular energy production. AMPK gene expression levels also recovered in the patients given CoQ10 treatment. Notably, one of the AMPK enzyme functions is to instruct mitochondria to switch from using energy to producing energy.
The researchers have previously studied the link between mitochondrial dysfunction, oxidative stress and inflammation in fibromyalgia. Based on the study results, they concluded that CoQ10 could be part of an effective therapy for fibromyalgia."
Holtorf recommends the ubiquinol form:
"CoQ10 comes in two forms – ubiquinol, the active antioxidant form, and ubiquinone, the oxidized form, which the body partially converts to ubiquinol. Many multi-ingredient supplements contain both forms, however, ubiquinol has greater antioxidant efficiency than the ubiquinone form."
Another study:
"In Redox Report, researchers looked at increased oxidative stress and CoQ10 deficiency in juvenile fibromyalgia patients. Lab tests conducted at the beginning of the study showed that children with fibromyalgia had significantly decreased serum plasma levels of ubiquinol, and a significantly increased ratio of ubiquinone (oxidized CoQ10) to total CoQ10, compared to healthy controls, suggesting that fibromyalgia is associated with CoQ10 deficiency and increased oxidative stress, according to the researchers.
Next, the researchers supplemented the children with 100 mg per day of ubiquinol-10 for 12 weeks. The patients saw significant improvements in chronic fatigue scores, as well increased Co10 levels and decreased ubiquinone levels. The researchers concluded that CoQ10 status may be impaired in subjects with juvenile fibromyalgia and that supplementation with CoQ10 may be of benefit."
Wow....
).
