How newco Citryll B.V.'s antibody could treat autoimmune diseases

J William M Tweedie

Well-Known Member
Downstream without a NET

By Stephen Parmley, Senior Writer
Published on Thursday, July 9, 2015
ModiQuest Research B.V. has discovered that its therapeutic mAb against citrullinated histones has the potential to treat autoimmune diseases by inhibiting the formation of neutrophil extracellular traps that play a role in the pathogenesis of autoimmunity. Because it acts on pathways downstream of PAD, the mAb may have fewer side effects than PAD inhibitors already in development.
Last month, ModiQuest spun out Citryll B.V. as a single-asset company to develop the lead therapeutic anti-citrullinated protein antibody (tACPA) for inflammatory diseases such as rheumatoid arthritis (RA).

Paid subscription required for full article. BioCentury
 

Cort

Founder of Health Rising and Phoenix Rising
Staff member
Downstream without a NET

By Stephen Parmley, Senior Writer
Published on Thursday, July 9, 2015
ModiQuest Research B.V. has discovered that its therapeutic mAb against citrullinated histones has the potential to treat autoimmune diseases by inhibiting the formation of neutrophil extracellular traps that play a role in the pathogenesis of autoimmunity. Because it acts on pathways downstream of PAD, the mAb may have fewer side effects than PAD inhibitors already in development.
Last month, ModiQuest spun out Citryll B.V. as a single-asset company to develop the lead therapeutic anti-citrullinated protein antibody (tACPA) for inflammatory diseases such as rheumatoid arthritis (RA).

Paid subscription required for full article. BioCentury
It sounds like a new approach to autoimmunity - at least to me :) - and that's a good thing.
 

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