Increased Low- and High-Frequency Oscillatory Activity in the Prefrontal Cortex of PWFM

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http://journal.frontiersin.org/article/10.3389/fnhum.2016.00111/full

In summary, this study demonstrates that FM patients present enhanced low- and high-frequency oscillatory activity in the brain areas related to cognitive and emotional modulation of pain. Increased low- and high-frequency activity of the prefrontal cortex may contribute to persistent perception of pain in FM. Therapeutic intervention based on manipulating neural oscillation to restore normal thalamocortical rhythmicity may be beneficial to pain relief in FM.