Inhibit Lactate Dehydrogenase?

[Remy]

If ME/CFS patients tend to overutilise the lactate dehydrogenase pathway, rather than the pyruvate pathway, might it be useful to employ some lactate dehydrogenase inhibitors?

There is accumulating evidence to suggest that abnormally high lactate levels and intracellular acidosis exhibited in patients with CFS/ME are the result of impaired mitochondrial function [61, 63]. For example, CFS/ME patients exhibit profound and sustained intracellular acidosis of the peripheral musculature following relatively low-level exercise. This results in a decreased anaerobic threshold (AT) due to an overutilisation of the lactate dehydrogenase pathway [15, 41].

https://www.hindawi.com/journals/jar/2016/2497348/

There are many natural lactate dehydrogenase inhibitors available according to the table in the following paper. I wonder if this strategy, perhaps combined with something like dichloroacetate, would be enough to push the body back in the direction of utilizing the mitochondria. Either that or it would simply rob the body of all sources of energy to our detriment. Hard to know. Anyone have any experience with these herbs?

PMC full text:
European J Med Plants. Author manuscript; available in PMC 2014 Jan 27.
Published in final edited form as:
European J Med Plants. 2013; 3(4): 603–615.
Published online 2013.
Copyright/License ►Request permission to reuse

Table 1

Natural source aqueous extracts with human LDH-A inhibitory potency by rank

Rank​

ID No.​

Common ± Chinese Name​

Scientific Name​

IC 50 mg/ml​

IC 50 μg/ml​

1​

M22​

Wu Bei Zi​

Melaphis chinensis gallnut​

0.00009​

0.09​

4​

B53​

Babul Chall Bark​

Acacia arabica​

0.00075​

0.75​

2​

F17​

Bladderwrack​

Fucus vesiculosus​

0.00100​

1.00​

3​

K06​

Kelp Powder​

Laminaria Japonica​

0.00134​

1.34​

5​

B13​

Bayberry Root bark​

Morella cerifera​

0.00158​

1.58​

6​

C8​

CraneSbill Root​

Geranium maculatum​

0.00173​

1.73​

7​

A78​

Arjun​

Terminalia arjuna​

0.00183​

1.83​

8​

P54​

Ye Jiao Ten​

Polygonum multiflorum vine​

0.00288​

2.88​

9​

P56​

Mu Dan Pi​

Paeonia suffructicose root - bark​

0.00298​

2.98​

10​

W2​

Witch Hazel Root​

Hamamelis virginiana​

0.00321​

3.21​

11​

P82​

Pipsissewa​

Chimaphila umbellata​

0.00410​

4.10​

12​

C82​

Cinnamon powder​

Cinnamon powder​

0.00434​

4.34​

13​

R19​

Rose Buds and Petals Pink​

Rosa Rugosa Flower​

0.00478​

4.78​

14​

C10​

Cat Claw Bark​

Uncaria tomentosa​

0.00483​

4.83​

15​

D10​

Dryopteris Male Fern Rhizome​

Dryopteris crassirhizoma​

0.00636​

6.36​

16​

R25​

Rhodiola Root​

Rhodiola kirilowii​

0.00809​

8.09​

17​

T30​

Turkey Rhubarb​

Rheum palmatum​

0.00958​

9.58​

18​

G26​

Wintergreen​

Gaultheria procumbens​

0.01086​

10.86​

19​

XT76​

Longon Peel​

Dimocarpus longan​

0.01195​

11.95​

20​

H12​

Gloryvine Stem​

Sargentodoxa cuneata vine​

0.01260​

12.60​

21​

M6​

Meadowsweet Powder​

Filipendula ulmaria​

0.01566​

15.66​

22​

N2​

Neem Leaf​

Azadirachta indica​

0.01836​

18.36​

23​

T25​

Sang Ji Sheng​

Taxillus chinensis stem & leaf​

0.02060​

20.60​

24​

C32​

Cynomorium songaricum​

Cynomorium songaricum​

0.02150​

21.50​

25​

P55​

Chi Shao​

Paeonia Lactiflora​

0.02283​

22.83​

26​

P83​

Pygeum Bark​

Pygeum africanum​

0.02623​

26.23​

27​

P8​

Hu Zhang​

Polygonum cuspidatum rhizome​

0.02842​

28.42​

28​

XT 8​

Green Tea​

Camellia sinensis​

0.02852​

28.52​

29​

XT91​

Longon stem​

Dimocarpus longan​

0.02973​

29.73​

30​

A1​

Agrimony​

Agrimonia eupatoria​

0.03072​

30.72​

31​

L46​

Linden Leaf​

Tilia europaea​

0.03152​

31.52​

32​

A63​

Sha Ren Guang​

Amomum villosum fruit Shelled​

0.04040​

40.40​

33​

W16​

White Willow Bark​

Salix alba​

0.04108​

41.08​

34​

W15​

White Oak Bark​

Quercus alba​

0.04154​

41.54​

35​

G40​

Guarana Seed​

Paullinia cupana​

0.04253​

42.53​

36​

S11​

St Johns Wort​

St Johns Wort​

0.04408​

44.08​

37​

L25​

Lychee Pit​

Litchi chinesis seed​

0.04592​

45.92​

38​

H4​

Hawthorne Leaf and Flower​

Crataegus laevigata​

0.04790​

47.90​

39​

P13​

Bian u​

Polygonum aviculare herb​

0.05264​

52.64​

40​

N1​

Nutmeg​

Myristica fragans​

0.05811​

58.11​

41​

S8​

Saw Palmetto Berry​

Serenoa repens​

0.06608​

66.08​

42​

M38​

Maiden Hair Fern​

Adiantum capillus​

0.06847​

68.47​

43​

T4​

Truja twigs, c/s​

Thuja occidentalis Cupressaceae​

0.07676​

76.76​

44​

P29​

Wei Ling Cai​

Potentilla chinensis herb​

0.07772​

77.72​

 

[Paw]

Either that or it would simply rob the body of all sources of energy to our detriment. Hard to know. Anyone have any experience with these herbs?

That's a good question. And a good list. I'll have to return to some of these herbs with a focus on tracking lactate-type reactions. Rhodiola, guarana, etc. Trouble is, many have other roles that are pretty powerful (e.g. St John's Wart) so pinpointing effects on lactate could be messy business. But definitely worth keeping an eye on.

 

[Cort]

If ME/CFS patients tend to overutilise the lactate dehydrogenase pathway, rather than the pyruvate pathway, might it be useful to employ some lactate dehydrogenase inhibitors?



https://www.hindawi.com/journals/jar/2016/2497348/

There are many natural lactate dehydrogenase inhibitors available according to the table in the following paper. I wonder if this strategy, perhaps combined with something like dichloroacetate, would be enough to push the body back in the direction of utilizing the mitochondria. Either that or it would simply rob the body of all sources of energy to our detriment. Hard to know. Anyone have any experience with these herbs?

PMC full text:
European J Med Plants. Author manuscript; available in PMC 2014 Jan 27.
Published in final edited form as:
European J Med Plants. 2013; 3(4): 603–615.
Published online 2013.
Copyright/License ►Request permission to reuse

Table 1

Natural source aqueous extracts with human LDH-A inhibitory potency by rank

Rank​

ID No.​

Common ± Chinese Name
Scientific Name​

IC 50 mg/ml
IC 50 μg/ml​

1​

M22​

Wu Bei Zi
Melaphis chinensis gallnut​

0.00009
0.09​

4​

B53​

Babul Chall Bark
Acacia arabica​

0.00075
0.75​

2​

F17​

Bladderwrack
Fucus vesiculosus​

0.00100
1.00​

3​

K06​

Kelp Powder
Laminaria Japonica​

0.00134
1.34​

5​

B13​

Bayberry Root bark
Morella cerifera​

0.00158
1.58​

6​

C8​

CraneSbill Root
Geranium maculatum​

0.00173
1.73​

7​

A78​

Arjun
Terminalia arjuna​

0.00183
1.83​

8​

P54​

Ye Jiao Ten
Polygonum multiflorum vine​

0.00288
2.88​

9​

P56​

Mu Dan Pi
Paeonia suffructicose root - bark​

0.00298
2.98​

10​

W2​

Witch Hazel Root
Hamamelis virginiana​

0.00321
3.21​

11​

P82​

Pipsissewa
Chimaphila umbellata​

0.00410
4.10​

12​

C82​

Cinnamon powder
Cinnamon powder​

0.00434
4.34​

13​

R19​

Rose Buds and Petals Pink
Rosa Rugosa Flower​

0.00478
4.78​

14​

C10​

Cat Claw Bark
Uncaria tomentosa​

0.00483
4.83​

15​

D10​

Dryopteris Male Fern Rhizome
Dryopteris crassirhizoma​

0.00636
6.36​

16​

R25​

Rhodiola Root
Rhodiola kirilowii​

0.00809
8.09​

17​

T30​

Turkey Rhubarb
Rheum palmatum​

0.00958
9.58​

18​

G26​

Wintergreen
Gaultheria procumbens​

0.01086
10.86​

19​

XT76​

Longon Peel
Dimocarpus longan​

0.01195
11.95​

20​

H12​

Gloryvine Stem
Sargentodoxa cuneata vine​

0.01260
12.60​

21​

M6​

Meadowsweet Powder
Filipendula ulmaria​

0.01566
15.66​

22​

N2​

Neem Leaf
Azadirachta indica​

0.01836
18.36​

23​

T25​

Sang Ji Sheng
Taxillus chinensis stem & leaf​

0.02060
20.60​

24​

C32​

Cynomorium songaricum
Cynomorium songaricum​

0.02150
21.50​

25​

P55​

Chi Shao
Paeonia Lactiflora​

0.02283
22.83​

26​

P83​

Pygeum Bark
Pygeum africanum​

0.02623
26.23​

27​

P8​

Hu Zhang
Polygonum cuspidatum rhizome​

0.02842
28.42​

28​

XT 8​

Green Tea
Camellia sinensis​

0.02852
28.52​

29​

XT91​

Longon stem
Dimocarpus longan​

0.02973
29.73​

30​

A1​

Agrimony
Agrimonia eupatoria​

0.03072
30.72​

31​

L46​

Linden Leaf
Tilia europaea​

0.03152
31.52​

32​

A63​

Sha Ren Guang
Amomum villosum fruit Shelled​

0.04040
40.40​

33​

W16​

White Willow Bark
Salix alba​

0.04108
41.08​

34​

W15​

White Oak Bark
Quercus alba​

0.04154
41.54​

35​

G40​

Guarana Seed
Paullinia cupana​

0.04253
42.53​

36​

S11​

St Johns Wort
St Johns Wort​

0.04408
44.08​

37​

L25​

Lychee Pit
Litchi chinesis seed​

0.04592
45.92​

38​

H4​

Hawthorne Leaf and Flower
Crataegus laevigata​

0.04790
47.90​

39​

P13​

Bian u
Polygonum aviculare herb​

0.05264
52.64​

40​

N1​

Nutmeg
Myristica fragans​

0.05811
58.11​

41​

S8​

Saw Palmetto Berry
Serenoa repens​

0.06608
66.08​

42​

M38​

Maiden Hair Fern
Adiantum capillus​

0.06847
68.47​

43​

T4​

Truja twigs, c/s
Thuja occidentalis Cupressaceae​

0.07676
76.76​

44​

P29​

Wei Ling Cai
Potentilla chinensis herb​

0.07772
77.72​

Great Stuff Remy! I'm going to send this link to the Davis's....