http://www.medpagetoday.com/Blogs/EPMonthly/51359
Low dose ketamine appears to have excellent pain reducing properties. It can also potentiate the effects of opioids - thus cutting the dosage needed for them.
However, it also has analgesic properties (an advantage over an agent like Propofol which is a pure sedative) and these analgesic effects are still present even in lower doses. In addition, through its action as an NMDA receptor antagonist, ketamine can also potentiate the analgesic effect of opioids, allowing lower doses of opioids. These properties are the reason there is now a growing body of evidence supporting the analgesic potential of sub-anesthetic, or low dose ketamine for acute pain in the emergency department (ED).
Low dose ketamine appears to have excellent pain reducing properties. It can also potentiate the effects of opioids - thus cutting the dosage needed for them.
However, it also has analgesic properties (an advantage over an agent like Propofol which is a pure sedative) and these analgesic effects are still present even in lower doses. In addition, through its action as an NMDA receptor antagonist, ketamine can also potentiate the analgesic effect of opioids, allowing lower doses of opioids. These properties are the reason there is now a growing body of evidence supporting the analgesic potential of sub-anesthetic, or low dose ketamine for acute pain in the emergency department (ED).