It's the master detoxifier and studies indicate it is low in ME/CFS but GSH also appears to play a major role in the immune system
https://www.sciencedaily.com/releases/2017/04/170418120923.htm
." Further tests performed by Prof. Brenner's team demonstrated the reason for this: "The mice cannot produce any glutathione in their T-cells," Prof Brenner continues, "and so a number of other signalling events that directly boost metabolism and increase energy consumption are lacking." As a result, without glutathione, T-cells do not become fully functional; they remain in their state of hibernation and no self-destructive autoimmune response occurs. Prof Karsten Hiller from the Braunschweig University of Technology who collaborated with the Luxembourgish scientists
https://www.sciencedaily.com/releases/2017/04/170418120923.htm
." Further tests performed by Prof. Brenner's team demonstrated the reason for this: "The mice cannot produce any glutathione in their T-cells," Prof Brenner continues, "and so a number of other signalling events that directly boost metabolism and increase energy consumption are lacking." As a result, without glutathione, T-cells do not become fully functional; they remain in their state of hibernation and no self-destructive autoimmune response occurs. Prof Karsten Hiller from the Braunschweig University of Technology who collaborated with the Luxembourgish scientists