Losing upper body fat and collagen, high oxidative stress? Leaky gut? Anyone else?

[Maryrichards]

Hi, I am losing adipose tissue in my upper body, so losing all the fat around my collarbone, chest ,shoulders yet gaining fat around the middle. I am just all bone in those areas. My doctor has sent some to some specialists but nothing has come of that. I take Florenif for POTS. I have read that this drug rarely can cause some side effects like thinning skin. But I think this was slowly starting before I began taking the florenif.. Ive had fibro and cfs for 10+ years, ibs and now Gerd. I did the OAT test a year ago which showed bacterial and fungal overgrowth, treated that then recently took the MOAT test which showed still bacterial and fungal overgrowth but also higher good bacteria so have been treating that and the gerd.
just wondering if anyone else is experiencing this mysterious loss of fat tissue. Its quite significant and also my collagen and elastin seems depleted in my skin. The past year the skin on my body has become loose, sagging and draping. I haven’t been able to exercise for years but still this seems extreme. Doctor told me a few years ago I had high oxidative stress. I’m new on this forum so not sure if I’m doing this correcty. Anyone else dealing with this?

 

[Carl#1]

I don't have an answer to your fat problems TBH.

However collagen and skin need high amounts, 1/3 of the amino acids in these tissues are Glycine and high cortisol levels which tend to be present in these illnesses will tend to cause breakdown of these tissues to supply Glycine. High levels of inflammation require Glutathione which also requires three amino acids and Glycine is one of those three. That means there is a high Glycine requirement. However Glycine can raise GABA levels and promote sleep. Glutamate is needed to balance GABA.

I don't suggest that you wildly supplement with Glycine before you research it's full effects but it does sound like you need more of it but you need to find a way of getting it without any adverse effects.

The bacterial overgrowth comes from your stomach function most likely. Check for Urease by testing with an acid and see if your stomach generates wind ie carbon dioxide as the acid reacts with Urease enzyme.

Leaky Gut causes inflammation from LipoPolySaccharides (LPS) and immune reactions to foods and that needs anti inflammatories where Glutathione is the main one in the human body.