Hi All, I started having symptoms in the early 2000s and since the very start of testing whenever doctors have run a standard liver function panel my Alkaline Phosphatase (ALP) comes back low. And every time they say it is irrelevant since it only matters if it's high. But as a PhD myself who can't help but research I periodically set out to investigate and find...well, basically nothing (except mentions of malnutrition, which I suppose could be possible if there is malabsorbtion/leaky gut, and Wilson's Disease, which I don't have). So I'd look, find nothing, forget about it. Recently, however, I was prescribed Xyrem for sleep, and after having several horrific experiences, learned I needed to start at the dose typically recommended for those with hepatic dysfunction. Indeed I am super sensitive to most medications/supplements I take, as well as to alcohol and while there could be many reasons, it got me thinking about ALP again (which, turns out, the testing looks at overall, although ALP subtypes may be from bone, mitchochondria, other sources in addition to liver). Looking on this forum I noticed others have mentioned low ALP (Mellster back in 2012, Neunistiva, Winterwren, Bjjpapi this year) but others have had high. Thought I'd see about numbers.