Supplement Magnesium Plus Malic Acid is the Key?


Founder of Health Rising and Phoenix Rising
Staff member
Prohealth has a pretty long blog on how combining magnesium with malic acid is important.
They suggest low magnesium could be contributing to reduced serotonin levels (pain), high substance P (more pain) and low ATP (low energy).
  • Magnesium is involved in the production of serotonin. Serotonin is a neurotransmitter involved in regulating sleep cycles, pain perception, mood and the immune system. People with fibromyalgia typically have low serotonin levels, which can be related to the sleep disturbances, increased pain and mood problems they often experience.
  • A magnesium deficiency can cause an increase of substance P. Substance P is a neurotransmitter that serves as a pain messenger. People with fibromyalgia usually have exceptionally high levels of substance P, which can contribute to their hypersensitivity to pain.
  • Magnesium activates adenosine triphosphate (ATP). Energy is supplied to our bodies by the mitochondria in the form of ATP. Researchers have found evidence of mitochondrial dysfunction in fibromyalgia patients, which would result in the severe fatigue reported by most.(3)

    Fibromyalgia and Malic Acid Deficiency

    Researchers have found that people with fibromyalgia have decreased levels of oxygen in their muscles, also known as muscle hypoxia. Biopsies of those muscles have shown muscle tissue breakdown, mitochondrial damage, and low levels of ATP, which helps explain the widespread muscle pain characteristic of FM.
They said leading ME/CFS physicians recommend this combination:

A number of leading ME/CFS specialists, including Daniel Peterson, MD, Jay Goldstein, MD, Jacob Teitelbaum, MD, Charles Lapp, MD, and Paul Cheney, MD, recommend a combination of malic acid and magnesium for muscle health and improved energy.

In his “From Fatigued to Fantastic” newsletter, Dr. Teitelbaum said, “Magnesium and malic acid are also critical. When malic acid and the other compounds are low, the body often has to shift to the very inefficient (anaerobic) means of generating energy. This contributes to the abnormal buildup of lactic acid that occurs after exercise in CFIDS/FM. This causes muscle achiness and fatigue."

It sounds like it's the cat's meow ???


Well-Known Member
The combo really worked well for me............helped with that feeling of lactic acid with muscle rigidity/knots occurring after certain activities.


Well-Known Member
I found that when I started supplementing with magnesium on a regular basis that I couldn't stay awake. I was sleeping through the night which was great, but I wanted to sleep all day also. :(


Well-Known Member
Just a thought Tiger: you might check out dicaffeine malate (I haven't yet) -- a synergized combo of stable caffeine and malic acid.


Well-Known Member
Just a thought Tiger: you might check out dicaffeine malate (I haven't yet) -- a synergized combo of stable caffeine and malic acid.
I can't have caffeine as it makes me really hyper and speeds up my heart rate. :(

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