Mirtazapine (Remeron)?

Autumn

New Member
Anyone on this antidepressant for sleep?

I took it in the past, combining it with Efexor at the time. It did help me sleep then. But apart from that I have horrible experience with antidepressants. As in no effect on mood or being completely emotionally numb, side effects, and horrible withdrawals.

I'm worried about taking it again (seriously, I'm crying about it :rolleyes: - and not because I'm depressed).
I've been on sick leave for the past 4 months after a crash. Worst one so far, after 10+ years of this illness.

Gp suggested either this or Trazodone. But I've had a bad reaction to the latter after taking it once in the past. Combining it with Bupropion at the time, which was the possible culprit.

Anyway, I definitely need (deep) sleep and to be able to eat as I have some bad GI issues.
Any thoughts on whether this is a good idea or not?

Thanks
 

Not dead yet!

Well-Known Member
Anyone on this antidepressant for sleep?

I took it in the past, combining it with Efexor at the time. It did help me sleep then. But apart from that I have horrible experience with antidepressants. As in no effect on mood or being completely emotionally numb, side effects, and horrible withdrawals.

I'm worried about taking it again (seriously, I'm crying about it :rolleyes: - and not because I'm depressed).
I've been on sick leave for the past 4 months after a crash. Worst one so far, after 10+ years of this illness.

Gp suggested either this or Trazodone. But I've had a bad reaction to the latter after taking it once in the past. Combining it with Bupropion at the time, which was the possible culprit.

Anyway, I definitely need (deep) sleep and to be able to eat as I have some bad GI issues.
Any thoughts on whether this is a good idea or not?

Thanks

No antidepressants work on me at all, genetic issue. One of them, Celexa, is tolerable if I ramp it up over a month and only in maximum 25mg doses, total dose, which has to be divided as well. Not worth the effort.
But I have a slightly controversial suggestion: the gut issues can sometimes temporarily go away with a carnivore diet. As in meat and water, nothing else. No FODMAPS, no anti-nutrients from plants, no fiber, pure protein and fat. Or at least to avoid FODMAPS and have much more meat than usual. It's kind of cultish, but it did work for me at times. Here's a respectable doctor talking about it (video/audio): https://www.biohackerslab.com/ep19-dr-shawn-baker/

Be aware that not all carnivore websites offer foods I would consider "healthy" there are far too many fake bread recipes out there which I don't consider good for health. A nice meatloaf is healthier than powdered pork rind flour. Too weird.

There are some real life stories here: https://zerocarbzen.com/tag/carnivore/

I haven't committed to a fully carnivore diet. Just not convinced it's a permanent solution. But it does help and I can see which foods cause me allergies more easily now.
 

EddieB

Member
So sorry you’re down, going through a bad crash myself.

My Gastrointest talked me into going on mirt about 6 months ago. I too have GI issues as a major part of my problem, and wasn’t able to sleep more than 4 or 5 hours a night. He believes my CNS/vagus nerve is the root cause of my reflux and IBS; I’m not so sure.

I was terrified because I’d read of so many bad/mixed reviews on mirt. The first few days were awful, as it set off my cfs/fatigue/gastric issues and made them much worse. Gradually it subsided and actually I had several weeks of feeling somewhat better with better energy and less symptoms. Then for whatever reason, it just stopped working. Fatigue and nausea came back and I’m on the couch ever since.

It’s possible that I would have felt better regardless, as that happens every once and a while. The doctor insists it’s helping and needs more time to work. What bothers me is why it made all my symptoms so much worse initially. Btw, I began by cutting pills to 3.5mg to start off. I’m at 22.5mg now. I do sleep ok with it, some crazy dreams at first, not bad now. But it does cause restless leg for me. It is a strange medicine, higher doses are known to cause insomnia. Not really noticing any anti depressant/mood changes at this dose. It did make me hungry at first, but that too has worn off, normal appetite now.

So I’m continuing to take it for now to appease the doctor, but I don’t think it’s
much help. At least it doesn’t seem to be hurting anything and I’m sleeping. If you do try it again, I’d start at a very low dose and only use what you need for sleep. Again, lower doses are more sedative. If I go off it at some point, I’ll cut pills and taper slowly.

My focus right now, is turning toward gut/virus/micro biome. I recently found out about Dr Chia and the research he is doing, and believe that for some of us with cfs/gastrointestinal issues, this could be where part of the problem lies. My illness started with what felt like a stomach virus. Trying to get one of my doctors to work with him remote, since there is no way I could get to him.

Not sleeping makes everything worse. Hope you get some rest!
E.
 

Autumn

New Member
Thanks for the replies!

Not sleeping or eating makes everything worse indeed.

I decided to give it another go. Starting at 15mg at night. Gave me a headache, restless legs, and some agitation the first 2 days. I split the tablet to 7.5mg which is better. Still gives me a bit of a headache. Sleep seems somewhat better (lots of dreaming though?) and I'm still awake for about an hour before actually falling asleep. It does give me more appetite. My nausea is gone, which definitely is a plus.

Mirtazapine does have a weird profile with the sedation a lower doses.
Anyway, so far so good, but not planning to be on this forever.
I'm worried about this apparent trend to take these sort of meds for life. Unless it would be an actual cure.
 
Autumn i have find help for sleeping problems with lemon balm, liposomal melatonin, l-theanine .

Liposomal melatonin is a detox and antioxidant and also calms gut symptoms too...currently taking various dosages,since it`s not just for sleep but also detoxing brain. It can give headache in the morning or some brain fog, but i think it is not the melatonin itself, but simply detox symptoms as toxins like aluminium start moving , 6-8 mg has been my usual lately .

Magnesium malate also, becouse aluminium is one thing that causes insomnia, and the malic acid chelate it plus gives magnesium which is also important for relaxitation,sleep .
 
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EddieB

Member
Autumn,
Any updates on how you’re getting on with mirtazapine?
I’m going to try reducing my dose, from 22.5 to 15. I’ve been going over my notes and trying to figure out why my fatigue has gotten so much worse.

I did pretty good on 15mg. But it seems My energy really started downhill about 8 weeks after going up to 22.5. They say it takes 6-8 weeks for it to take full effect. It’s a strange med and has different effects for everyone.

I’ve also had some dry skin/rashes, restless leg, slowed digestion and other odd symptoms that could be related. Other than ok sleep, I don’t see any benefits from it. We’ll see what happens.
 

Autumn

New Member
Autumn,
Any updates on how you’re getting on with mirtazapine?
I’m going to try reducing my dose, from 22.5 to 15. I’ve been going over my notes and trying to figure out why my fatigue has gotten so much worse.

I did pretty good on 15mg. But it seems My energy really started downhill about 8 weeks after going up to 22.5. They say it takes 6-8 weeks for it to take full effect. It’s a strange med and has different effects for everyone.

I’ve also had some dry skin/rashes, restless leg, slowed digestion and other odd symptoms that could be related. Other than ok sleep, I don’t see any benefits from it. We’ll see what happens.
Hi EddieB,

Well, I only took it for one month.
I was sleeping I guess. In fact, I felt like I was dreaming (at times restlessly) a lot more. Not sure about getting more deep sleep. And the nausea was gone. It definitely made me eat. But it took too long to wear off during the day. I felt I was only waking up properly past mid day and after a few cups of coffee.
I decided to go off it which gave me worse fatigue for a week and also made me crash a bit. Bad sensory overload. I'd say, go slow with the tapering.

If I think about it:
- 15 mg: sleep ok though lots of dreaming, nausea is gone, restless legs (which doesn't help sleep onset), does give me energy in the afternoon though agitated, somewhat less pain (?), headaches
- 7,5 mg: sleep though lots of dreaming, nausea gone but annoying food/sugar cravings, restless legs (less than on 15mg), some water retention

I guess I could say it helped a bit but it mostly feels fake if that makes sense? I know lots of people would say 'who care if it's fake, if it makes you feel better' but I'm worried about this false sense of 'energy' which makes me do things and then makes me crash. After one week of mirtazapine I actually thought 'awesome, I'll be going to work next month' but I felt like I was doing things on this agitated sort of energy while my body/brain can't actually handle it. I went through antidepressant withdrawal twice after one year of treatment on both occasions. It was terrible. Coming off mirtazapine after only one month now already feels rough.

My gp asked me to try 25 mg of Trazodone at night. Only took it once so far but it kept me up most of the night. Go figure?
So I haven't been taking anything for the past 10 days. I was doing okay and my sleep wasn't too bad. I sort of took a break from it all and went away for a few days. It was okay, sleep and eating weren't too bad, was able to do some walking. But I've been having a bit of a crash again these past 3 days. Bad fatigue, headache, pain, nausea in the morning.

Not sure what to do...

Keep me posted!
 

EddieB

Member
I get what you mean about feeling a “fake” improvement. Totally makes sense now. It made me so sick initially, then that passed and I did have energy, but it was kind of a agitated, wired energy. Maybe it gave me a false sense of wellness and I burned out?

I was told to keep increasing the dose slowly up to 30mg. Then around last Sept, I started downhill, so I dropped back to 22.5. Kept feeling weaker and weaker, until totally crashed/ housebound. Couldn’t figure out why, no changes otherwise.

It never really helped the nausea. Did have more appetite at first, but it passed. I sleep, but with the crazy dreams, not sure it’s quality. I was told over and over, give it time; I think it’s had enough...

I dropped back to 15mg, 3 days ago, and I seem to have a slight bit more energy. Too soon to tell, but I think I’m going stay at 15 a while, then continue to slowly reducing the dose and see what happens. So confusing, these meds may make us feel better short term, but eventually they poop out. I had a similar go with amitriptyline a few years ago.

Good thing you weren’t on it too long.
Hope your crash passes soon...
 
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