Modified Citrus Pectin Increases B, T and NK Cells.

Remy

Administrator
It's apparently also useful in the process of removing biotoxins from mold (gentler than CSM) and can help with heavy metal chelation.

Activation of Human T-Helper/Inducer Cell, T-Cytotoxic Cell, B-Cell, and Natural Killer (NK)-Cells and induction of Natural Killer Cell Activity against K562 Chronic Myeloid Leukemia Cells with Modified Citrus Pectin
Cheppail Ramachandran1*, Barry J Wilk2, Arland Hotchkiss34, Hoa Chau3, Isaac Eliaz2 and Steven J Melnick15
Author Affiliations
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BMC Complementary and Alternative Medicine 2011, 11:59 doi:10.1186/1472-6882-11-59
Published: 4 August 2011
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Abstract

Background

Modified citrus pectin (MCP) is known for its anti-cancer effects and its ability to be absorbed and circulated in the human body. In this report we tested the ability of MCP to induce the activation of human blood lymphocyte subsets like T, B and NK-cells.
Methods

MCP treated human blood samples were incubated with specific antibody combinations and analyzed in a flow cytometer using a 3-color protocol. To test functionality of the activated NK-cells, isolated normal lymphocytes were treated with increasing concentrations of MCP. Log-phase PKH26-labeled K562 leukemic cells were added to the lymphocytes and incubated for 4 h. The mixture was stained with FITC-labeled active form of caspase 3 antibody and analyzed by a 2-color flow cytometry protocol. The percentage of K562 cells positive for PKH26 and FITC were calculated as the dead cells induced by NK-cells. Monosaccharide analysis of the MCP was performed by high-performance anion-exchange chromatography with pulse amperometric detection (HPAEC-PAD).
Results

MCP activated T-cytotoxic cells and B-cell in a dose-dependent manner, and induced significant dose-dependent activation of NK-cells. MCP-activated NK-cells demonstrated functionality in inducing cancer cell death. MCP consisted of oligogalacturonic acids with some containing 4,5-unsaturated non-reducing ends.
Conclusions

MCP has immunostimulatory properties in human blood samples, including the activation of functional NK cells against K562 leukemic cells in culture. Unsaturated oligogalacturonic acids appear to be the immunostimulatory carbohydrates in MCP.
 

Cort

Founder of Health Rising and Phoenix Rising
Staff member
Modified citrus pectin! Isn't that something. The more they dig into nature - the more they find.
 

Who Me?

Well-Known Member
The Pectin you can buy in groceries stores for canning is used by people wanting to pass drug tests.

I bought some years ago to detox something. I forget what now. Maybe Mercury

Maybe the same theory?
 

Remy

Administrator
Why is it modified? How is it modified? Has anyone tried regular old citrus pectin made by MN (Mother Nature)? :)
We can't absorb regular pectin well from our intestines which is why it is a good source of fiber in our diets.

The modified citrus pectin is a smaller molecule that can be absorbed into the bloodstream so it can do the work of binding toxins that regular pectin cannot. It also can bind to the galectin 3 molecule which is abundant on cancer tumor cells. This may help stop the spread of cancer though this has not been well studied or proven in human trials.
 

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