TCA cycle is the citric acid cycle, so this is in line with what Ron Davis (and others?) has been saying. exciting to see similar results in different research teams. Does anyone know if this is the Japanese team Bateman-Horne is cooperating with? (remember the video about the blood samples sent to Japan?)Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles
Emi Yamano, Masahiro Sugimoto, Akiyoshi Hirayama, Satoshi Kume, Masanori Yamato, Guanghua Jin, Seiki Tajima, Nobuhito Goda, Kazuhiro Iwai, Sanae Fukuda, Kouzi Yamaguti, Hirohiko Kuratsune, Tomoyoshi Soga, Yasuyoshi Watanabe & Yosky Kataoka
Received:23 June 2016
Accepted:21 September 2016
Published online:11 October 2016
Chronic fatigue syndrome (CFS) is a persistent and unexplained pathological state characterized by exertional and severely debilitating fatigue, with/without infectious or neuropsychiatric symptoms, lasting at least 6 consecutive months. Its pathogenesis remains incompletely understood. Here, we performed comprehensive metabolomic analyses of 133 plasma samples obtained from CFS patients and healthy controls to establish an objective diagnosis of CFS. CFS patients exhibited significant differences in intermediate metabolite concentrations in the tricarboxylic acid (TCA) and urea cycles. The combination of ornithine/citrulline and pyruvate/isocitrate ratios discriminated CFS patients from healthy controls, yielding area under the receiver operating characteristic curve values of 0.801 (95% confidential interval [CI]: 0.711–0.890, P < 0.0001) and 0.750 (95% CI: 0.584–0.916, P = 0.0069) for training (n = 93) and validation (n = 40) datasets, respectively. These findings provide compelling evidence that a clinical diagnostic tool could be developed for CFS based on the ratios of metabolites in plasma.
Some info on the urea cycle here. It's basically a metabolic process that transforms ammonium (=byproduct of breakdown of amino acids) into urea, which leaves the body via urine. If that system is faulty I guess nothing good can come from it, as both ammonium and urea are toxic to the human body.The tricarboxylic acid cycle (TCA cycle) is a series of enzyme-catalyzed chemical reactions that form a key part of aerobic respiration in cells. This cycle is also called the Krebs cycle and the citric acid cycle.