This NIH-funded study is the culmination of years of effort and several past studies. NIH-funded studies are rare in ME/CFS - and they get noticed when they are published; let's make sure they can get this done as soon as possible. They need a few more people to complete the study. This study attempts to show that people with ME/CFS have reduced blood flows to the brain, increased lactate levels, reduced antioxidant levels, and increased oxidative stress; i.e. their brains are a mess. Along with that, they're attempting to show ME/CFS brains are different from the brains of people with major depression, and that the oxidative stress problems are found body-wide - in the brain, blood, and urine. It's a fantastic study. People in the study should not be taking brain altering meds for anxiety, depression, insomnia or pain for at least a week, and live within commuting distance of New York City (in order to get reimbursed for travel. If you don't need to be reimbursed for travel then you can come from anywhere ) The study simply requires filling out some questionnaires, getting an MRI done and taking some blood and urine tests. If you'd like to participate please use the contact form on the Pain and Fatigue website and/or call 212-844-6665. Check out a description of the study from ProjectReporter below.