Fibromyalgia Novel Pain Treatments

Discussion in 'Relieving Pain' started by Steve, Jul 31, 2018.

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  1. Steve

    Steve Active Member

    I decided to start yet another thread here to see if anyone has tried unusual treatments for FM pain and had any success. I'm frankly too tired right now to list all of those I've tried that one might regard as novel (especially since none have worked) but I did have a question for members. Has anyone tried shrooms i.e. " magic mushrooms" which contain psilocybin or derivatives? Someone I know well just went to Amsterdam recently and tried level one 1 shrooms (they go up to 5) and had a life changing experience. He was wondering if they might help my FM severe pain, even for the 4-6 hours the experience lasts. Psilocybin, while illegal here in U.S., has a remarkably safe profile for both psychological and biological effects. It intensifies sensory experience to a huge degree. It is uncertain as to whether such effect would be positive or negative for FM pain, a sensory condition regardless of how you conceptualize it. I would be interested in knowing if anyone has tried it via shrooms for FM. I have never used hallucinogens so this would be a pretty big deal. Of course, any other novel treatments are also welcomed here.
     
  2. Cort

    Cort Founder of Health Rising and Phoenix Rising Staff Member

    I have Michael Pollan's new book on just this subject. Haven't read it yet but it's intriguing.

    I'll have a blog coming out soon on another new pain treatment.

    I assume that you've tried LDN?
     
  3. Steve

    Steve Active Member

    Hi Cort,
    I vaguely knew Pollan had written one but it had slipped into old age memory, will check my libe, thx.
    I tried LDN years ago before I was on Tramadol, no effect until I hit 2.5 mg when my pain went to 10 in exactly the spot where it had started 25 years earlier, my skull bones. I 'm still on Tramadol, lots now, but am considering trying ULDN as there is someone on my meds on an FB thread also trying it and I thought I'd follow that.
    The shrooms scare me though they have a "good" safety record and supposedly have only temporary effects. The person I know said it was one of the top five profound experiences in his life and is flying back to Amsterdam to do it again in a week, just two weeks first his first trial. Wants me to go with him sometime. IDK...
     
  4. Cort

    Cort Founder of Health Rising and Phoenix Rising Staff Member

    How about cannabis? Can really help with pain.

    https://www.nytimes.com/2018/06/04/books/review/michael-pollan-how-to-change-your-mind.html
     
  5. Paw

    Paw Well-Known Member

    I've been using an alcohol-based CBD rub, which I find is only mildly helpful for myalgias, but significantly helpful for neurological pain and burning (if you deal with that). Haven't done mushrooms in decades, but I think they'd certainly be educational if nothing else.
     
  6. Steve

    Steve Active Member

    I haven't been able to get MJ to work for me, spent hours researching, decarboxing, making and buying edibles, couch locked me but no pain relief. Tried infused pads and also had CBD massages and drunk a ton of the stuff, makes me a little fuzzy but also no pain relief.

    I spent a lot of time under green lights of a certain frequency published by several AZ doctors, article not handy, no pain relief. I tried SAD level lights just a bit years ago but am going to follow this protocol from 2017 with two lights when my second light arrives.
    https://www.ncbi.nlm.nih.gov/pubmed/27473633.

    Running out of even novel treatment options.
     
  7. SuzyDee

    SuzyDee Member

    Look into nitrates for a novel neuropathic pain med. Not much around on the subject but one small study found GTN patches to be effective for diabetic peripheral neuropathy.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665823/

    All nitrates can help with pain via exploiting opening of potassium channels so oral ones such as isosorbide can do the trick too. Under the tongue sprays or sublinguals are too short acting in their action to be of much use though.

    A potassium channel opener med that has been in clinical use as a nonopioid analgesic in Europe since 1984 is flupirtine. Retigabine (known as ezogabine in the US) was an anti-seizure med very closely related to flupirtine which was going to undergo clinical trials in the US for Fibromyalgia a couple of years back but I see this med has been withdrawn from market now and I don't know if the Fibro trial ever ever kicked off.
     
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  8. Steve

    Steve Active Member

    Thanks, will check out, though my PCP "managing" (i.e. keep taking your tramadol and Tylenol and look for another specialist LOL) won't prescribe nitro for me.
    I followed the Pub Med study with ten female fibro patients using two SAD lights for a week. They got diminished pain, altered circadian rhythm, and other good effects, though to a limited degree. I had no benefits. This is also related to the neurohormone system, though, and all studies are done with females. no one knows if male fibro patients should receive similar treatments.

    Dr. Gillis finally just got approval for his TB vaccine modification for fibro treatment after six years, as noted on his Facebook page for the FM/test. He was supposed to be ready to go when he got this but is a terrible communicator and organizer with his clinical subjects, who all paid or had insurance to get into the study, some six years ago. Anyone who achieved a certain level of cytokines on his blood test is supposed to receive the vaccine. I am not happy with the delay.
     
  9. SuzyDee

    SuzyDee Member

    Nitrates work via boosting nitric oxide (NO). Similarly, so do over the counter NO booster supplements like arginine, citrulline or even beet powder. These don't have the same potency or immediacy as prescription nitrates but in theory, should work too, probably more as a slow cumulative effect though.

    Alternatively, tadalafil (Cialis) has some benefit as a pain med too. It has been used for renal colic pain too or another severe pain syndrome called Loin Pain Hematuria Syndrome.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575214/
     
  10. Steve

    Steve Active Member

    Ah, I've taken citrulline with no effect I could find and also add watermelon powder to my oatmeal every morning for same reason and antioxidants. As for Cialis, not only are the side effects unpleasant, the main effect is pretty pronounced and, personally, I would find it difficult to use merely for pain reasons. I didn't notice any drop in pain using it.
     
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