Role of UDCA/TUDCA in Mast Cell Disease?

Discussion in 'Mast Cell and Histamine' started by Remy, Jul 8, 2016.

  1. Remy

    Remy Administrator

    I wrote a post on the benefits of TUDCA here to help correct protein misfolding and ER stress.

    But now I'm reading that some mast cell patients are prescribed ursodiol (UDCA) to manage mast cell reactions caused by bile. I'm not sure I understand how exactly that works though...does anyone else know?

    From what I can find, some bile acids seem to be secretory and others are non-secretory. The secretory ones can cause diarrhea. Taking TUDCA/UDCA changes the composition of the bile acids to a less toxic version and may help reduce diarrhea. But I'm still not entirely clear how all that ties into the mast cells yet.

    TUDCA has been studied and found equivalent to UDCA in one to one doses. It may also be more tolerable than UDCA. And it's non-prescription, go figure.

    And FWIW, UDCA has also been studied as a cell membrane stabilizer useful in some central nervous system disorders. It's also used for it's immunomodulatory action in AIDS patients.

    Starting to wonder why this benign drug isn't a first line treatment for ME/CFS and MCAS...
    Veet likes this.
  2. Who Me?

    Who Me? Well-Known Member

    So do we want it or not and does if it doesn't cause diahrea (which might be a bonus for me) does it make constipation worse?

    I remember reading about this before and meant to add it to my tbd list.
  3. Remy

    Remy Administrator

  4. Who Me?

    Who Me? Well-Known Member

    What language is that? I don't read Martian. Lol :drowning:
    Veet likes this.
  5. Veet

    Veet Well-Known Member

    I've been following along this very long thread. TUDCA is central to the conversation, but this is the first time I've seen references to mast cells, as far as I can recall. Due to the higher cost of TUDCA, I requested an rx from my GP for UDCA, but never bothered to fill it and give it a try, as I'm not having overt gb issues. You've just given me more incentive.
    Remy and Who Me? like this.
  6. Who Me?

    Who Me? Well-Known Member

    The cost is why I didn't get any. I remember that thread well. I like the red warning "Do it at your own risk." Isn't that with everything we do? @Veet
  7. Remy

    Remy Administrator

    Do it! You can be the guinea this time...:)
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  8. Remy

    Remy Administrator

    So here's more...looks like it modulates the eosinophils, which may act similarly to the mast cells.

    You can see your eosinophil count on a typical CBC. You want this to be 2-3% and elevations above this may indicate allergic disease.

  9. Who Me?

    Who Me? Well-Known Member

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  10. Issie

    Issie Well-Known Member

    I've tried it. One brand was better than another. I react to food dyes and one has red capsules. Was not good. The other one was. I don't know if it helped MCAS or not. I'm having a bad case of it. Got triggered by MMS. That was not a good experiment. Maybe will try it again.
  11. Remy

    Remy Administrator

    I know! I was so pissed when I got those red caps! The Chizled brand (barf) is white.

    I'm ready to go to UDCA though because it's a cheaper rx than TUDCA is a supplement.