Ron Davis Calls for NIH To Take New Approach To Disease with Chronic Fatigue Syndrome (ME/CFS)

Discussion in 'ME/CFS and FM News' started by Cort, Jul 2, 2016.

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  1. Cort

    Cort Founder of Health Rising and Phoenix Rising Staff Member

    In his response to the NIH's request for Information on ME/CFS Ron Davis called for a massive effort to understand the molecular roots of ME/CFS. This effort would require the NIH to fund studies focused on developing hypotheses instead of answering them. It would result in new ways to analyse proteins, cells and data. Researchers would develop new ways to collaborate. In effect, Davis is trying to usher in a new approach to researching diseases and producing treatments. He argues that such an approach would benefit many. (The full text is below)

    An Overview



    The Stanford Chronic Fatigue Syndrome Research Center (this is the Davis Stanford Center not Montoya Stanford center) is focused on producing not just a diagnostic biomarker but a molecular diagnostic biomarker; that is, it is focused one finding the shakers and movers in ME/CFS at the cellular level.

    A Parkinson's Connection?

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    It was fascinating that Davis has found transcriptomic (gene), and metabolic (breakdown products of the cell) overlaps with Parkinson's Disease. Parkinson's, in fact, was the only other disease directly mentioned in connection with ME/CFS. It's hard to know how much to read into that mention, but the possible connections between the two diseases - which until recently have hardly ever been mentioned together - are intriguing. Both could be classified as movement disorders, both involve the basal ganglia, both appear to feature reductions in dopamine and inflammation probably plays a major role in both.

    From a funding and research perspective, getting ME/CFS allied with Parkinson's - a major neurodegenerative disease - would, of course, be quite helpful.

    A Parkinson's - ME/CFS connection could be the kind of surprise we get as researchers dig deeper into the molecular underpinnings of ME/CFS.

    More Host Response Than Infection

    Davis doesn't appear to put as much faith in the idea that an active infection is causing ME/CFS, as he does that an infection or other stressor probably triggers a more or less system-wide "hypometabolic" or low energy state. (One wonders if Nath's metabolic chamber is going to pick up that hypometabolism.) A system-wide hypometabolic state could explain one of the conundrums in ME/CFS - how so many different systems could be affected.

    Davis suggests that ME/CFS has a strong genetic/environmental component. It may be that the genetic factors that underpin this disease get expressed only under certain circumstances such as during an infection or some other trauma. Absent those circumstances, ME/CFS never appears.

    Davis noted that even mitochondria diseases - which are largely genetically determined - may remain unmasked until an infectious event occurs. This underscores Davis's belief that the host response to infection is the key, not necessarily the infection itself.

    A New Approach To Disease

    Davis acknowledges that ME/CFS is likely a very heterogeneous disease but asserts that the way to understanding that heterogeneity is for research efforts to get even more precise. Given our ability now to effectively assess astounding amounts of data, he believes that researchers should engage in massive molecular profiling studies that use new advanced computational techniques to pluck out the heterogeneity present.

    How to get those exploratory studies, funded, though, given the NIH's penchant for hypothesis driven studies? Have the NIH produce more "open" RFA's that explicitly call for studies to generate hypotheses. (If the NIH wants a hypothesis driven study the hypothesis could be "We hypothesize that this study will allow us to generate valid hypotheses regarding ME/CFS :))

    Davis also wants the NIH to create a collaborative mechanism that allows researchers across the world to share data. To that end innovative new computational techniques that allow researchers to share and analyse data across multiple databases should be developed. (With his Harvard/Stanford connection Davis has already enrolled researchers in developing new ways to analyse the enormous amounts of data the OMF's project is creating.)

    In fact, Davis believes that chronic fatigue syndrome with all its complexity offers the opportunity for the medical field to develop new ways to study complex diseases.

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    (Despite its small size the ME/CFS research field has been an incubator of new techniques. Suzanne Vernon produced one of the first attempts ever to merge clinical, genomic and lab data while at the CDC. Gordon Broderick is doing cutting edge modeling and computational analyses at the Institute for Neuro-Immune Medicine. In order to test treatments more quickly Jarred Younger wants to produce a way to fast-track trials at the Neuroinflammation, Pain and Fatigue Laboratory.)

    Davis wants to develop better and more sensitive ways to characterize molecular and cellular data and new computational methods to analyze them. He believes the techniques developed to do that could provide breakthroughs in other diseases.

    There's something to being in on the expansion of a field that lends itself to creativity. Because ME/CFS hasn't been well studied it hasn't been captured by one hypothesis or one field of thought. Researchers know that they don't know and they know they need to develop ways to learn as quickly and comprehensively as possible. Developing ways to more or less quickly produce well-founded hypotheses may be the main gift the ME/CFS field can, at this point, provide for other diseases.

    Interestingly, Davis emphasized the need for long term studies - something that has rarely if ever happened - but which the Center for Infection and Immunity is now featuring. He closed by making a plea for an open and collaborative effort that brings together researchers of all kinds to solve the many questions facing ME/CFS.


    The Full Text is Below

     
    Last edited: Jul 2, 2016
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  2. PamJ

    PamJ Active Member

    Maybe I'm crazy, but the more detailed Davis gets, the more worried I get. I guess I worry that the results he finds in severely ill patients won't help those of us with moderate CFS-ME. I also worry that if our illness is similar to mitochondrial deficiency, there will be no solid treatments.
     
  3. Issie

    Issie Well-Known Member

    My doc at Mayo feels his patients with POTS do have mitro issues. He puts us on a "cocktail " to support it.
    Here is my latest thing to start looking into - Iodine. It helps support the mitochondria and many other things. This is a long read, but interesting.

    http://treeoflifecenterus.com/blog-...olistic-super-mineral-2/#sthash.e3B12pMQ.dpuf

    Issie
     
  4. EYAKLLE

    EYAKLLE Guest

  5. Cort

    Cort Founder of Health Rising and Phoenix Rising Staff Member

    It's funny I feel just the opposite :).
    Since I think most people who have severe ME/CFS often spend quite a bit of time having moderate ME/CFS - I'll bet he will find commonalities.
    I had the same concern about the mitochonria but Davis believes, I believe, that the problem with the mitochondria probably comes from something in the blood that is shutting them off. That would make a much easier treatment target. Time will tell!
     
  6. San Diego

    San Diego Well-Known Member

    This. :)
     
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  7. Cort

    Cort Founder of Health Rising and Phoenix Rising Staff Member

    Agreed! I think the patient community agrees ;)
     
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  8. This is my favourite Paragraph
    ...This shift in thinking opens up the possibility that ME/CFS has strong genetic and environmental associations, which may also explain the extensive heterogeneity in its presentation, progression, and recovery across patients. The search for novel infectious agents should continue, but research efforts should also focus on understanding individual host susceptibility and response to infection. For example, it may not be a particular infectious agent that results in the disease, but rather a particular host state as a function of numerous biological and external factors that governs an individual’s susceptibility....
    Yes, Yes Yes. One of the original names was 'Allergic to the 20th Century', later it was ME and CFS, all 3 of which adequately explains what happened in a whole body response, add systemic candidiasis, severe gastric problems, exhaustion etc.
    Yes atopic, genetic reactions that were not apparent in our extended family previous to the massive onslaught of agricultural and petro-chemicals, including airbourne and ingested in water, food and medications, that we now take for granted. This toxic environment which we now accept as 'Normal' not only causes illnesses such as ME but is also appearing as road rage, domestic violence etc. etc.
    Abnormal behaviour of any description shows the human body to be stressed beyond current adaption. Those of us with it are the canaries down the coal mine. Humanity should be grateful for the warning provided by our increased sensitivity. But will governments listen and will they, can they, act?
     
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  9. Bottsie

    Bottsie Member


    I had similar concerns with the testing of the severely ill. I have always been moderately affected, only occasionally lapsing into a severe state. However, those concerns were allayed when OMF announced that the Moderately Ill leg of the study was funded and ready to get underway. For what it's worth, my money is on Dr. Davis' team. I call them the Dream-Come-True Team. They are independently funded and not as constricted by strings attached to government funding. Plus, Dr. Davis is uniquely motivated in finding a treatment/cure for his son, Whitney. Anxiously awaiting the results of the first study. :angelic::bookworm:
     
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  10. Cort

    Cort Founder of Health Rising and Phoenix Rising Staff Member

    Crossing my fingers...
     
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