Founder of Health Rising and Phoenix Rising
They found one chemical, then tweaked it to make it more potent and then gave it to mice. The mice didn't display any of the behaviors associated with opioid side effects. (Mice get addicted to opioids as well).
"I think this was really a tour de force," says Gavril Pasternak, a researcher at the Memorial Sloan Kettering Cancer Center who's also trying to develop new opioids but was not involved in this study. "They're new entities with totally different pharmacological profiles. These are great promise for opiates over the course of the next five to 10 years."
Manglik and some of his collaborators have founded a company that will try to bring these new drugs to market, and the pharmaceutical company Trevena is running a very similar molecule through clinical trials now.