Supplemental Biotin Interferes with Many Lab Tests.

[Remy]

If you've looked at all the recent metabolomics work lately and thought, hmmm, biotin, like I did, you should be aware that high doses of biotin will interfere with many lab test assays, including many common thyroid tests.

Biotin is water soluble though and a washout for testing should be possible fairly quickly considering the half life is under 2 hours. Stopping it for even a day would likely be sufficient, 3 days would be an abundance of caution.

An Issue with Assays
The problem is that almost all immunoassays today contain biotin because they rely on the biotin–streptavidin attraction to either anchor the assay’s antibodies to a capture surface or capture them once they have reacted with a patient sample, according to Stefan K. Grebe, MD, PhD, professor of laboratory medicine & pathology and co-director of the endocrine laboratory at the Mayo Clinic in Rochester, Minn.

Large amounts of biotin in a patient sample can interfere with this process. However, the effects can be confusing because, depending on the particular assay, biotin can skew the results to be either falsely high or falsely low. In the case of competitive immunoassays — usually used for low molecular weight targets (such as T4, T3, and cortisol) — biotin interference causes a falsely high result. In immunometric (sandwich) assays, it gives a falsely low result.

- See more at: http://endocrinenews.endocrine.org/january-2016-thyroid-month-beware-of-biotin/#sthash.2bqEGHRx.dpuf

 

[Hip]

Good to know. I take 5,000 mcg of biotin daily.