the stanford paradox vs the Ron Davis study

phillybadboy

New Member
The difference is 2,3dpg, one had it in the serum the other did not.
Ron Davis study in mononuclear cells abnormalities possibly in glycolysis , and impedance , addition of pyruvate made the normal . 2,3dpg levels are higher in cfs . It is released from the muscle and maybe brain too into the bloodstream and taken by mononuclear cells . 2,3dpg inhibits hk, pfk, gapd . this results in lower glycolytic intermediates and pyruvate . Less pyruvate is available for oxidative phosphorylation , this is why when they added pyruvate the cells behaved normally .

the Standford study showed higher levels of atp production from nonmitochondrial sources ( probably glycolysis ). The mononuclear cells from cfs patients in this study became adapted to the inhibition by 2,3dpg , they tried to increase their activity to cope with the inhibition by 2,3dpg . when the study was done with patient mononuclear cells but not with patient serum ( the 2,3dpg is in patient serum ) the 2,3dpg inhibition of the glycolytic enzymes has been lifted so that now the glycolytic enzymes became overly activated , hence the higher levels of atp through higher levels of glycolysis.
 

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