Abstract
We reviewed the use of oral dichloroacetate (DCA) in the treatment of children with congenital lactic acidosis caused by mutations in the pyruvate dehydrogenase complex (PDC). The case histories of 46 subjects were analyzed with regard to diagnosis, clinical presentation and response to DCA.
DCA decreased blood and cerebrospinal fluid lactate concentrations, and was generally well tolerated. DCA may be particularly effective in children with PDC deficiency by stimulating residual enzyme activity and, consequently, cellular energy metabolism.
A controlled trial is needed to determine the definitive role of DCA in the management of this devastating disease.
I understand that Skip Pridgen went to 2 grams 4 times a day instead of 500mgs 4X. Is that right?
Health Rising's ME/CFS and Fibromyalgia Sleep SeriesHR's blog sleep series prompted by the passing of an ME/CFS patient from poor sleep
"Recovering From Hypothyroidism" Website and Series From Paul RobinsonPatient Advocate provides detailed look at possible thyroid issues in ME/CFS and FM
"Recovering From Hypothyroidism" Series From Paul RobinsonPaul Robinson's comprehensive guides to hypothyroidism including low T3 syndrome
![ME/CFS lecture | Dr Nancy Klimas | 2011 [Chronic Fatigue Syndrome / SEID / New Zealand] - YouTube](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
